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Predictors of folate status among pregnant Japanese women : the Hokkaido Study on Environment and Children's Health, 2002-2012

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Title: Predictors of folate status among pregnant Japanese women : the Hokkaido Study on Environment and Children's Health, 2002-2012
Authors: Yila, Thamar A. Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Itoh, Kumiko Browse this author
Ikeno, Tamiko Browse this author →KAKEN DB
Yoshioka, Eiji Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Baba, Toshiaki Browse this author
Braimoh, Titilola Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Endo, Toshiaki Browse this author →KAKEN DB
Sengoku, Kazuo Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Folate status
Pregnancy
Tobacco smoking
Hokkaido Study on Environment and Children’s Health
Issue Date: Jun-2016
Publisher: Cambridge University Press
Journal Title: British Journal of Nutrition
Volume: 115
Issue: 12
Start Page: 2227
End Page: 2235
Publisher DOI: 10.1017/S0007114516001628
PMID: 27121118
Abstract: The International Clearinghouse for Birth Defects, Surveillance and Research reports a rise in the prevalence rate of spina bifida in Japan. We determined first-trimester folate status of Hokkaido women and identified potential predictors. Participants were 15 266 pregnant women of the Hokkaido Study on Environment and Children’s Health Cohort. Data were extracted from self-reported questionnaires and biochemical assay results. Demographic determinants of low folate status were younger maternal age (adjusted OR (AOR) 1·48; 95 % CI 1·32, 1·66), lower educational level (AOR 1·27; 95 % CI 1·17, 1·39) and lower annual income (AOR 1·11; 95 % CI 1·01, 1·22). Plasma cotinine concentrations of 1·19-65·21 nmol/l increased the risk of low folate status (AOR 1·20; 95 % CI 1·10, 1·31) and concentrations >65·21 nmol/l further increased the risk (AOR 1·91; 95 % CI 1·70, 2·14). The most favourable predictor was use of folic acid (FA) supplements (AOR 0·19; 95 % CI 0·17, 0·22). Certain socio-demographic factors influence folate status among pregnant Japanese women. Modifiable negative and positive predictors were active and passive tobacco smoking and use of FA supplements. Avoiding both active and passive tobacco smoking and using FA supplements could improve the folate status of Japanese women.
Rights: © The Authors 2016
Type: article
URI: http://hdl.handle.net/2115/65838
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木 敦子

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