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Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis

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Title: Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis
Authors: Ishizu, Akihiro Browse this author →KAKEN DB
Tomaru, Utano Browse this author →KAKEN DB
Masuda, Sakiko Browse this author
Sada, Ken-ei Browse this author
Amano, Koichi Browse this author
Harigai, Masayoshi Browse this author →KAKEN DB
Kawaguchi, Yasushi Browse this author →KAKEN DB
Arimura, Yoshihiro Browse this author
Yamagata, Kunihiro Browse this author →KAKEN DB
Ozaki, Shoichi Browse this author →KAKEN DB
Dobashi, Hiroaki Browse this author
Homma, Sakae Browse this author
Okada, Yasunori Browse this author →KAKEN DB
Sugiyama, Hitoshi Browse this author
Usui, Joichi Browse this author
Tsuboi, Naotake Browse this author
Matsuo, Seiichi Browse this author
Makino, Hirofumi Browse this author →KAKEN DB
Keywords: Microscopic polyangiitis
Prediction of response to treatment
Gene profiling
Peripheral blood
Issue Date: 31-May-2017
Publisher: BioMed Central
Journal Title: Arthritis Research & Therapy
Volume: 19
Issue: 1
Publisher DOI: 10.1186/s13075-017-1328-7
PMID: 28569178
Abstract: Background: Microscopic polyangiitis (MPA), which is classified as an anti-neutrophil cytoplasmic antibody (ANCA)- associated small vessel vasculitis, is one of the most frequent primary vasculitides in Japan. We earlier nominated 16 genes (IRF7, IFIT1, IFIT5, OASL, CLC, GBP-1, PSMB9, HERC5, CCR1, CD36, MS4A4A, BIRC4BP, PLSCR1, DEFA1/DEFA3, DEFA4, and COL9A2) as predictors of response to remission induction therapy against MPA. The aim of this study is to determine the accuracy of prediction using these 16 predictors. Methods: Thirty-nine MPA patients were selected randomly and retrospectively from the Japanese nationwide RemIT-JAV-RPGN cohort and enrolled in this study. Remission induction therapy was conducted according to the Guidelines of Treatment for ANCA-Associated Vasculitis published by the Ministry of Health, Labour, and Welfare of Japan. Response to remission induction therapy was predicted by profiling the altered expressions of the 16 predictors between the period before and 1 week after the beginning of treatment. Remission is defined as the absence of clinical manifestations of active vasculitis (Birmingham Vasculitis Activity Score 2003: 0 or 1 point). Persistent remission for 18 months is regarded as a “good response,” whereas no remission or relapse after remission is regarded as a “poor response.” Results: “Poor” and “good” responses were predicted in 7 and 32 patients, respectively. Five out of 7 patients with “poor” prediction and 1 out of 32 patients with “good” prediction experienced relapse after remission. One out of 7 patients with “poor” prediction was not conducted to remission. Accordingly, the sensitivity and specificity to predict poor response was 85.7% (6/7) and 96.9% (31/32), respectively. Conclusions: Response to remission induction therapy can be predicted by monitoring the altered expressions of the 16 predictors in the peripheral blood at an early point of treatment in MPA patients
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/66002
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石津 明洋

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