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Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/66039

タイトル: Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression
著者: Muramatsu, Daisuke 著作を一覧する
Okabe, Mitsuyasu 著作を一覧する
Takaoka, Akinori 著作を一覧する
Kida, Hiroshi 著作を一覧する
Iwai, Atsushi 著作を一覧する
発行日: 2017年 6月 6日
出版者: Nature Publishing
誌名: Scientific Reports
巻: 7
号: 1
開始ページ: 2831
出版社 DOI: 10.1038/s41598-017-03053-9
抄録: Black yeast, Aureobasidium pullulans is extracellularly produced β-(1,3), (1,6)-D-glucan (β-glucan) under certain conditions. In this study, using Glycine max cv. Kurosengoku (Kurosengoku soybeans), the production of β-glucan through fermentation of A. pullulans was evaluated, and the effects of A. pullulans cultured fluid (AP-CF) containing β-glucan made with Kurosengoku soybeans (kAP-CF) on a human monocyte derived cell line, Mono Mac 6 cells were investigated. Concentration of β-glucan in kAP-CF reached the same level as normal AP-CF. An anti-angiogenic protein, Thrombospondin-1 (THBS1) was effectively induced after the stimulation with kAP-CF for comparison with AP-CF. The THBS1 is also induced after stimulation with hot water extract of Kurosengoku soybeans (KS-E), while the combined stimulation of β-glucan with KS-E more effectively induced THBS1 than that with KS-E alone. These results suggest effects of A. pullulans-produced β-glucan on the enhancement of Kurosengoku soybean-induced THBS1 expression.
資料タイプ: article
URI: http://hdl.handle.net/2115/66039
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 岩井 淳

 

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