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Higenamine 4′-O-β-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through β2-adrenergic receptor
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Title: | Higenamine 4′-O-β-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through β2-adrenergic receptor |
Authors: | Kato, Eisuke Browse this author →KAKEN DB | Inagaki, Yosuke Browse this author | Kawabata, Jun Browse this author |
Keywords: | Nelumbo nucifera Gaertn. | hypoglycemic effect | glucose up take | β2-adrenergic receptor agonist | Diabetes mellitus |
Issue Date: | 1-Jul-2015 |
Journal Title: | Bioorganic & Medicinal Chemistry |
Volume: | 23 |
Issue: | 13 |
Start Page: | 3317 |
End Page: | 3321 |
Publisher DOI: | 10.1016/j.bmc.2015.04.054 |
PMID: | 25943853 |
Abstract: | Hypoglycemic effect is an efficient means to modulate elevated blood glucose levels in patients with diabetes. We found that the extract of lotus plumule (the germ of Nelumbo nucifera Gaertn. seed) showed potent glucose uptake enhancement activity against L6 myotubes, which results in a hypoglycemic effect. This activity was further investigated, and an active constituent was identified as a single bioactive compound, higenamine 4’-O-β-D-glucoside. chanistic studies employing phosphatidylinositol 3-kinase (PI3K) inhibitor, AMP-activated protein kinase (AMPK) inhibitor, or adrenergic receptor antagonist showed that the compound induced its activity through β2-adrenergic receptor. Patients with type II diabetes mellitus frequently develop insulin resistance. Owing to the differences between the mechanism of action of insulin and of the isolated compound, the compound or lotus plumule itself may have the possibility of modulating blood glucose levels in insulin-resistant patients effectively. |
Rights: | ©2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/66355 |
Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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