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Higenamine 4′-O-β-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through β2-adrenergic receptor

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Title: Higenamine 4′-O-β-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through β2-adrenergic receptor
Authors: Kato, Eisuke Browse this author →KAKEN DB
Inagaki, Yosuke Browse this author
Kawabata, Jun Browse this author
Keywords: Nelumbo nucifera Gaertn.
hypoglycemic effect
glucose up take
β2-adrenergic receptor agonist
Diabetes mellitus
Issue Date: 1-Jul-2015
Journal Title: Bioorganic & Medicinal Chemistry
Volume: 23
Issue: 13
Start Page: 3317
End Page: 3321
Publisher DOI: 10.1016/j.bmc.2015.04.054
PMID: 25943853
Abstract: Hypoglycemic effect is an efficient means to modulate elevated blood glucose levels in patients with diabetes. We found that the extract of lotus plumule (the germ of Nelumbo nucifera Gaertn. seed) showed potent glucose uptake enhancement activity against L6 myotubes, which results in a hypoglycemic effect. This activity was further investigated, and an active constituent was identified as a single bioactive compound, higenamine 4’-O-β-D-glucoside. chanistic studies employing phosphatidylinositol 3-kinase (PI3K) inhibitor, AMP-activated protein kinase (AMPK) inhibitor, or adrenergic receptor antagonist showed that the compound induced its activity through β2-adrenergic receptor. Patients with type II diabetes mellitus frequently develop insulin resistance. Owing to the differences between the mechanism of action of insulin and of the isolated compound, the compound or lotus plumule itself may have the possibility of modulating blood glucose levels in insulin-resistant patients effectively.
Rights: ©2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/66355
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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