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Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation : An in vivo microdialysis study

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Title: Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation : An in vivo microdialysis study
Authors: Kitta, Takeya Browse this author →KAKEN DB
Mitsui, Takahiko Browse this author →KAKEN DB
Kanno, Yukiko Browse this author
Chiba, Hiroki Browse this author
Moriya, Kimihiko Browse this author →KAKEN DB
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Shinohara, Nobuo Browse this author →KAKEN DB
Keywords: cystitis
glutamate
micturition reflex
periaqueductal gray
serotonin
Issue Date: Jul-2016
Publisher: Wiley-Blackwell
Journal Title: International journal of urology
Volume: 23
Issue: 7
Start Page: 593
End Page: 598
Publisher DOI: 10.1111/iju.13096
PMID: 27062256
Abstract: Objectives: To elucidate the possible involvement of glutamate and serotonin (5-hydroxytryptamine) neurons in the ventrolateral midbrain periaqueductal gray during noxious stimulation. Methods: The study was carried out by evoking a noxious stimulation by acetic acid in an animal model of cystitis. Changes in glutamate and 5-hydroxytryptamine in the periaqueductal gray during the micturition reflex and acetic acid-induced cystitis were determined using in vivo microdialysis combined with cystometry in rats. Results: Extracellular glutamate levels slightly, but significantly, increased during the micturition reflex induced by saline infusion into the bladder. Intravesical infusion of acetic acid facilitated the micturition reflex characterized by increases in voiding pressure and decreases in the intercontraction interval. Glutamate levels were markedly increased by acetic acid, and this enhancement was sustained for at least 3 h. 5-Hydroxytryptamine levels, which were not altered during the micturition reflex, were increased after intravesical infusion of acetic acid. Conclusion: The results suggest that periaqueductal gray glutamate and 5hydroxytryptamine neurons differentially participate in the modulation of both nociception and the micturition reflex. Furthermore, periaqueductal gray 5-hydroxytryptamine levels appear to reflect the nociceptive stimuli.
Rights: This is the peer reviewed version of the following article: Kitta, T., Mitsui, T., Kanno, Y., Chiba, H., Moriya, K., Yoshioka, M. and Shinohara, N. (2016), Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation: An in vivo microdialysis study. Int. J. Urol., 23: 593–598, which has been published in final form at http://dx.doi.org/10.1111/iju.13096. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/66404
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橘田 岳也

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