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Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation : An in vivo microdialysis study
| Title: | Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation : An in vivo microdialysis study |
| Authors: | Kitta, Takeya Browse this author →KAKEN DB | | Mitsui, Takahiko Browse this author →KAKEN DB | | Kanno, Yukiko Browse this author | | Chiba, Hiroki Browse this author | | Moriya, Kimihiko Browse this author →KAKEN DB | | Yoshioka, Mitsuhiro Browse this author →KAKEN DB | | Shinohara, Nobuo Browse this author →KAKEN DB |
| Keywords: | cystitis | | glutamate | | micturition reflex | | periaqueductal gray | | serotonin |
| Issue Date: | Jul-2016 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | International journal of urology |
| Volume: | 23 |
| Issue: | 7 |
| Start Page: | 593 |
| End Page: | 598 |
| Publisher DOI: | 10.1111/iju.13096 |
| PMID: | 27062256 |
| Abstract: | Objectives: To elucidate the possible involvement of glutamate and serotonin (5-hydroxytryptamine) neurons in the ventrolateral midbrain periaqueductal gray during noxious stimulation. Methods: The study was carried out by evoking a noxious stimulation by acetic acid in an animal model of cystitis. Changes in glutamate and 5-hydroxytryptamine in the periaqueductal gray during the micturition reflex and acetic acid-induced cystitis were determined using in vivo microdialysis combined with cystometry in rats. Results: Extracellular glutamate levels slightly, but significantly, increased during the micturition reflex induced by saline infusion into the bladder. Intravesical infusion of acetic acid facilitated the micturition reflex characterized by increases in voiding pressure and decreases in the intercontraction interval. Glutamate levels were markedly increased by acetic acid, and this enhancement was sustained for at least 3 h. 5-Hydroxytryptamine levels, which were not altered during the micturition reflex, were increased after intravesical infusion of acetic acid. Conclusion: The results suggest that periaqueductal gray glutamate and 5hydroxytryptamine neurons differentially participate in the modulation of both nociception and the micturition reflex. Furthermore, periaqueductal gray 5-hydroxytryptamine levels appear to reflect the nociceptive stimuli. |
| Rights: | This is the peer reviewed version of the following article: Kitta, T., Mitsui, T., Kanno, Y., Chiba, H., Moriya, K., Yoshioka, M. and Shinohara, N. (2016), Differences in neurotransmitter systems of ventrolateral periaqueductal gray between the micturition reflex and nociceptive regulation: An in vivo microdialysis study. Int. J. Urol., 23: 593–598, which has been published in final form at http://dx.doi.org/10.1111/iju.13096. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/66404 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 橘田 岳也
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