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Dietary Patterns and Risk of Esophageal Cancer Mortality : The Japan Collaborative Cohort Study

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Title: Dietary Patterns and Risk of Esophageal Cancer Mortality : The Japan Collaborative Cohort Study
Authors: Okada, Emiko Browse this author →KAKEN DB
Nakamura, Koshi Browse this author →KAKEN DB
Ukawa, Shigekazu Browse this author →KAKEN DB
Sakata, Kiyomi Browse this author →KAKEN DB
Date, Chigusa Browse this author →KAKEN DB
Iso, Hiroyasu Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: dietary pattern
esophageal cancer
cohort study
epidemiological study
Issue Date: 2016
Publisher: Taylor & Francis
Journal Title: Nutrition and cancer
Volume: 68
Issue: 6
Start Page: 1001
End Page: 1009
Publisher DOI: 10.1080/01635581.2016.1192202
PMID: 27366932
Abstract: Several case-control studies have associated dietary patterns with esophageal cancer (EC) risk, but prospective studies are scarce. We investigated dietary pattern and EC mortality risk associations by smoking status. Participants were 26,562 40- to 79-yr-old Japanese men, who enrolled in the Japan Collaborative Cohort Study between 1988 and 1990. Hazard ratios (HRs) and 95% confidence intervals (CIs) for EC mortality in nonsmokers and smokers were estimated using Cox proportional models. During follow-up (1988-2009), 132 participants died of EC. Using a baseline food frequency questionnaire and factor analysis, vegetable, animal, and dairy product food patterns were identified. EC risk decreased significantly with a higher factor score for the dairy product pattern (Ptrend = 0.042) and was more pronounced in smokers [multivariable HR (4th vs. 1st quartiles) = 0.57, 95% CI: 0.30, 1.09; Ptrend = 0.021]. Neither vegetable nor animal food patterns were significant overall; however, EC risk increased with a higher factor score for the animal food pattern in nonsmokers [multivariable HR (4th vs. 1st quartiles) = 6.01, 95% CI: 1.17, 30.88; Ptrend = 0.021], although the small number of events was a limitation. Our findings suggest a dairy product pattern may reduce EC risk in Japanese men, especially smokers.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer in 2016, available online:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡田 恵美子

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