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Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique


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タイトル: Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique
著者: Yamada, Takahiro 著作を一覧する
Miyamoto, Naoki 著作を一覧する
Matsuura, Taeko 著作を一覧する
Takao, Seishin 著作を一覧する
Fujii, Yusuke 著作を一覧する
Matsuzaki, Yuka 著作を一覧する
Koyano, Hidenori 著作を一覧する
Umezawa, Masumi 著作を一覧する
Nihongi, Hideaki 著作を一覧する
Shimizu, Shinichi 著作を一覧する
Shirato, Hiroki 著作を一覧する
Umegaki, Kikuo 著作を一覧する
キーワード: Tumor tracking
Spot scanning
Respiratory motion
Gated irradiation
発行日: 2016年 7月
出版者: Elsevier
誌名: Physica medica : European journal of medical physics
巻: 32
号: 7
開始ページ: 932
終了ページ: 937
出版社 DOI: 10.1016/j.ejmp.2016.06.002
抄録: Purpose: To find the optimum parameter of a new beam control function installed in a synchrotron-based proton therapy system. Methods: A function enabling multiple gated irradiation in the flat top phase has been installed in a real-time-image gated proton beam therapy (RGPT) system. This function is realized by a waiting timer that monitors the elapsed time from the last gate-off signal in the flat top phase. The gated irradiation efficiency depends on the timer value, Tw. To find the optimum Tw value, gated irradiation efficiency was evaluated for each configurable Tw value. 271 gate signal data sets from 58 patients were used for the simulation. Results: The highest mean efficiency 0.52 was obtained in TW = 0.2 s. The irradiation efficiency was approximately 21% higher than at TW = 0 s, which corresponds to ordinary synchrotron operation. The irradiation efficiency was improved in 154 (57%) of the 271 cases. The irradiation efficiency was reduced in 117 cases because the TW value was insufficient or the function introduced an unutilized wait time for the next gate-on signal in the flat top phase. In the actual treatment of a patient with a hepatic tumor at Tw = 0.2 s, 4.48 GyE irradiation was completed within 250 s. In contrast, the treatment time of ordinary synchrotron operation was estimated to be 420 s. Conclusions: The results suggest that the multiple gated-irradiation function has potential to improve the gated irradiation efficiency and to reduce the treatment time.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 宮本 直樹


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