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Strong cytoplasmic expression of NF-κB/p65 correlates with a good prognosis in patients with triple-negative breast cancer

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Title: Strong cytoplasmic expression of NF-κB/p65 correlates with a good prognosis in patients with triple-negative breast cancer
Authors: Baba, Motoi Browse this author
Takahashi, Masato Browse this author
Yamashiro, Katsushige Browse this author
Yokoo, Hideki Browse this author →KAKEN DB
Fukai, Moto Browse this author →KAKEN DB
Sato, Masanori Browse this author
Hosoda, Mitsuchika Browse this author →KAKEN DB
Kamiyama, Toshiya Browse this author →KAKEN DB
Taketomi, Akinobu Browse this author →KAKEN DB
Yamashita, Hiroko Browse this author →KAKEN DB
Keywords: NF-κB/p65
Triple-negative breast cancer
Neoadjuvant chemotherapy
Issue Date: Jul-2016
Publisher: Springer
Journal Title: Surgery today
Volume: 46
Issue: 7
Start Page: 843
End Page: 851
Publisher DOI: 10.1007/s00595-015-1265-5
PMID: 26494004
Abstract: Purpose: Recent studies have indicated that constitutive NF-κB activity could be involved in the proliferation of triple-negative breast cancer. Methods: NF-κB/p65 expression and the effects of the NF-κB inhibitor, (-)-DHMEQ were examined in triple-negative MDA-MB-231 breast cancer cells. Women with triple-negative breast cancer treated with neoadjuvant chemotherapy between 2002 and 2012 were retrospectively analyzed. Expression of NF-κB/p65, Bcl2 and Ki67 was examined by immunohistochemistry in pre- and post-treatment specimens, and predictive factors for neoadjuvant chemotherapy and prognosis were analyzed. Results: NF-κB/p65 was dominantly expressed in the cytoplasm in MDA-MB-231 cells. Of 34 triple-negative breast cancer patients, positive staining for NF-κB/p65 expression was detected in the nuclei of a few cells in 7 tumors before neoadjuvant chemotherapy, although expression of NF-κB/p65 in the cytoplasm was detected in almost all tumor cells of 33 tumors. Expression levels of NF-κB/p65 were not associated with response to neoaduvant chemotherapy, although expression levels of cytoplasmic NF-κB/p65 intensity were significantly decreased in post-treatment tumor samples compared with those in pretreatment samples. All patients whose tumors showed strong cytoplasmic NF-κB/p65 expression before neoadjuvant chemotherapy are currently disease-free. Conclusion: Our results suggest that strong cytoplasmic NF-κB/p65 expression could be a prognostic marker in triple-negative breast cancer.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山下 啓子

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