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Comparison of cardiac output measurements using transpulmonary thermodilution and conventional thermodilution techniques in anaesthetized dogs with fluid overload

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Title: Comparison of cardiac output measurements using transpulmonary thermodilution and conventional thermodilution techniques in anaesthetized dogs with fluid overload
Authors: Itami, Takaharu Browse this author →KAKEN DB
Endo, Yusuke Browse this author
Hanazono, Kiwamu Browse this author
Ishizuka, Tomohito Browse this author
Tamura, Jun Browse this author
Miyoshi, Kenjiro Browse this author
Sano, Tadashi Browse this author
Yamashita, Kazuto Browse this author →KAKEN DB
Keywords: cardiac output
dog
fluid overload
thermodilution
transpulmonary
Issue Date: Jul-2016
Publisher: Wiley-Blackwell
Journal Title: Veterinary Anaesthesia and Analgesia
Volume: 43
Issue: 4
Start Page: 388
End Page: 396
Publisher DOI: 10.1111/vaa.12331
PMID: 26671761
Abstract: Objective: To evaluate the agreement between cardiac output (CO) values obtained using a transpulmonary thermodilution technique (TPTDCO) and conventional thermodilution technique (TDCO) in anaesthetized dogs with fluid overload. Study design: Prospective experimental study. Animals: Six healthy Beagle dogs aged 7-8years. Methods: Dogs were anaesthetized with sevoflurane in oxygen, and catheters were inserted for TPTDCO and TDCO measurement. After instrumentation, baseline CO was measured using each technique at a central venous pressure (CVP) of 3-7mmHg. Dogs were subsequently administered lactated Ringer's solution and 6% hydroxyethyl starch to induce fluid overload. CO measurements were obtained using each technique at CVP values of 8-12mmHg, 13-17mmHg, 18-22mmHg and 23-27mmHg. Agreements between CO measurements obtained with the respective techniques were analysed using Dunnett's test, Pearson's correlation coefficient and Bland-Altman analysis. Results: Thirty pairs of CO values were obtained, ranging from 1.45Lminute(-1) to 4.69Lminute(-1) for TPTDCO and from 1.30Lminute(-1) to 4.61Lminute(-1) for TDCO. TPTDCO and TDCO values correlated strongly (r(2)=0.915, p<0.001). The bias and mean relative bias between TPTDCO and TDCO were 0.260.30Lminute(-1) (limits of agreement -0.29 to 0.81Lminute(-1)) and 9.7%, respectively. Conclusions and clinical relevance: TPTDCO and TDCO measurements obtained in anaesthetized dogs during fluid overload exhibited good agreement. Accordingly, transpulmonary thermodilution provides an accurate measurement of CO in dogs with fluid overload.
Rights: This is the peer reviewed version of the following article: Itami T, Endo Y, Hanazono K et al. (2015) Comparison of cardiac output measurements using transpulmonary thermodilution and conventional thermodilution techniques in anaesthetized dogs with fluid overload. Vet Anaesth Analg 43, 388-396, which has been published in final form at http://dx.doi.org/10.1111/vaa.12331. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/66557
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊丹 貴晴

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