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Comparison of cardiac output measurements using transpulmonary thermodilution and conventional thermodilution techniques in anaesthetized dogs with fluid overload
| Title: | Comparison of cardiac output measurements using transpulmonary thermodilution and conventional thermodilution techniques in anaesthetized dogs with fluid overload |
| Authors: | Itami, Takaharu Browse this author →KAKEN DB | | Endo, Yusuke Browse this author | | Hanazono, Kiwamu Browse this author | | Ishizuka, Tomohito Browse this author | | Tamura, Jun Browse this author | | Miyoshi, Kenjiro Browse this author | | Sano, Tadashi Browse this author | | Yamashita, Kazuto Browse this author →KAKEN DB |
| Keywords: | cardiac output | | dog | | fluid overload | | thermodilution | | transpulmonary |
| Issue Date: | Jul-2016 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Veterinary Anaesthesia and Analgesia |
| Volume: | 43 |
| Issue: | 4 |
| Start Page: | 388 |
| End Page: | 396 |
| Publisher DOI: | 10.1111/vaa.12331 |
| PMID: | 26671761 |
| Abstract: | Objective: To evaluate the agreement between cardiac output (CO) values obtained using a transpulmonary thermodilution technique (TPTDCO) and conventional thermodilution technique (TDCO) in anaesthetized dogs with fluid overload. Study design: Prospective experimental study. Animals: Six healthy Beagle dogs aged 7-8years. Methods: Dogs were anaesthetized with sevoflurane in oxygen, and catheters were inserted for TPTDCO and TDCO measurement. After instrumentation, baseline CO was measured using each technique at a central venous pressure (CVP) of 3-7mmHg. Dogs were subsequently administered lactated Ringer's solution and 6% hydroxyethyl starch to induce fluid overload. CO measurements were obtained using each technique at CVP values of 8-12mmHg, 13-17mmHg, 18-22mmHg and 23-27mmHg. Agreements between CO measurements obtained with the respective techniques were analysed using Dunnett's test, Pearson's correlation coefficient and Bland-Altman analysis. Results: Thirty pairs of CO values were obtained, ranging from 1.45Lminute(-1) to 4.69Lminute(-1) for TPTDCO and from 1.30Lminute(-1) to 4.61Lminute(-1) for TDCO. TPTDCO and TDCO values correlated strongly (r(2)=0.915, p<0.001). The bias and mean relative bias between TPTDCO and TDCO were 0.260.30Lminute(-1) (limits of agreement -0.29 to 0.81Lminute(-1)) and 9.7%, respectively. Conclusions and clinical relevance: TPTDCO and TDCO measurements obtained in anaesthetized dogs during fluid overload exhibited good agreement. Accordingly, transpulmonary thermodilution provides an accurate measurement of CO in dogs with fluid overload. |
| Rights: | This is the peer reviewed version of the following article: Itami T, Endo Y, Hanazono K et al. (2015) Comparison of cardiac output measurements using transpulmonary thermodilution and conventional thermodilution techniques in anaesthetized dogs with fluid overload. Vet Anaesth Analg 43, 388-396, which has been published in final form at http://dx.doi.org/10.1111/vaa.12331. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/66557 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 伊丹 貴晴
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