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The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity

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タイトル: The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity
著者: Tsuda, Yoshimi 著作を一覧する
Igarashi, Manabu 著作を一覧する
Ito, Ryo 著作を一覧する
Nishio, Sanae 著作を一覧する
Shimizu, Kenta 著作を一覧する
Yoshimatsu, Kumiko 著作を一覧する
Arikawa, Jiro 著作を一覧する
発行日: 2017年
出版者: Biomedical Research Press
誌名: Biomedical Research
巻: 38
号: 2
開始ページ: 89
終了ページ: 97
出版社 DOI: 10.2220/biomedres.38.89
抄録: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus responsible for causing an emerging zoonotic disease. We previously established subclones from SFTSV strain YG1 based on differences in low-pH-dependent cell fusion activities and found two amino acid substitutions, Y328H and R624W, in the envelope glycoprotein (GP) of high fusion subclones. In this study, we show that transiently expressed GP with the R624W mutation, but not the Y328H mutation, induced cell fusion under acidic conditions. GP possessing either tryptophan, serine, glycine or aspartic acid at position 624 induced cell fusion, whereas GP possessing basic amino acids such as arginine or lysine did not induce cell fusion. These results indicated that the amino acid at position 624 has an important role for inducing low-pH-dependent cell fusion.
資料タイプ: article
URI: http://hdl.handle.net/2115/66590
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 津田 祥美

 

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