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Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application
| Title: | Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application |
| Other Titles: | Dentin resorption and cementum-like tissue formation by BMP application | | Tissue reactions on BMP-applied dentin |
| Authors: | Miyaji, Hirofumi Browse this author →KAKEN DB | | Sugaya, Tsutomu Browse this author →KAKEN DB | | Kato, Katsuya Browse this author | | Kawamura, Naoto Browse this author | | Tsuji, Hifumi Browse this author | | Kawanami, Masamitsu Browse this author →KAKEN DB |
| Keywords: | BMP (bone morphogenetic protein) | | Dentin | | Resorption | | Cementum like tissue |
| Issue Date: | Aug-2006 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Journal of Periodontal Research |
| Volume: | 41 |
| Issue: | 4 |
| Start Page: | 311 |
| End Page: | 315 |
| Publisher DOI: | 10.1111/j.1600-0765.2006.00878.x |
| PMID: | 16827725 |
| Abstract: | Objective: This study aimed to examine the effect of bone morphogenetic protein-2 (BMP-2) application on dentin resorption and cementum-like tissue formation at the dentin surfaces.
Background: Recent studies showed that BMP-2 stimulated the mineralization and osteoclast differentiation. Osteoclastic resorption by BMP-2 application may play an important role in the regulation of new cementum-like tissue formation on the dentin surfaces.
Methods: Seventy-two flat dentin blocks were prepared from rat roots, treated with 24 % EDTA, applied with 0, 100, and 400 μg/ml BMP-2, and labeled as groups 0, 100, and 400. The dentin blocks were then implanted into palatal connective tissue of rats, and specimens were prepared at two, four and eight weeks after surgery for histologic and histomorphometric analyses.
Results: BMP-2 caused a dose-dependent increase in dentin resorption by osteoclastic cells. New cementum-like tissue was randomly formed on parts of the non-resorbed and resorbed dentin surfaces in groups 100 and 400. Dentin resorption in groups 100 and 400 was significantly greater than group 0 (p<0.01). However, at eight weeks new cementum-like tissue formed in 41.8% of group 100, as compared to 16.2% in group 400 (p<0.05).
Conclusion: Dentin resorption was stimulated by a high dose of BMP-2, and cementum-like tissue was induced by a low dose of BMP-2, effectively suggesting that BMP-2 application in an appropriate dose to a dentin surface may enhance periodontal regeneration. |
| Rights: | This is the peer reviewed version of the following article: [Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application], which has been published in final form at [https://doi.org/10.1111/j.1600-0765.2006.00878.x]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/66596 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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