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Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application

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Title: Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application
Other Titles: Dentin resorption and cementum-like tissue formation by BMP application
Tissue reactions on BMP-applied dentin
Authors: Miyaji, Hirofumi Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Kato, Katsuya Browse this author
Kawamura, Naoto Browse this author
Tsuji, Hifumi Browse this author
Kawanami, Masamitsu Browse this author →KAKEN DB
Keywords: BMP (bone morphogenetic protein)
Cementum like tissue
Issue Date: Aug-2006
Publisher: Wiley-Blackwell
Journal Title: Journal of Periodontal Research
Volume: 41
Issue: 4
Start Page: 311
End Page: 315
Publisher DOI: 10.1111/j.1600-0765.2006.00878.x
PMID: 16827725
Abstract: Objective: This study aimed to examine the effect of bone morphogenetic protein-2 (BMP-2) application on dentin resorption and cementum-like tissue formation at the dentin surfaces. Background: Recent studies showed that BMP-2 stimulated the mineralization and osteoclast differentiation. Osteoclastic resorption by BMP-2 application may play an important role in the regulation of new cementum-like tissue formation on the dentin surfaces. Methods: Seventy-two flat dentin blocks were prepared from rat roots, treated with 24 % EDTA, applied with 0, 100, and 400 μg/ml BMP-2, and labeled as groups 0, 100, and 400. The dentin blocks were then implanted into palatal connective tissue of rats, and specimens were prepared at two, four and eight weeks after surgery for histologic and histomorphometric analyses. Results: BMP-2 caused a dose-dependent increase in dentin resorption by osteoclastic cells. New cementum-like tissue was randomly formed on parts of the non-resorbed and resorbed dentin surfaces in groups 100 and 400. Dentin resorption in groups 100 and 400 was significantly greater than group 0 (p<0.01). However, at eight weeks new cementum-like tissue formed in 41.8% of group 100, as compared to 16.2% in group 400 (p<0.05). Conclusion: Dentin resorption was stimulated by a high dose of BMP-2, and cementum-like tissue was induced by a low dose of BMP-2, effectively suggesting that BMP-2 application in an appropriate dose to a dentin surface may enhance periodontal regeneration.
Rights: This is the peer reviewed version of the following article: [Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application], which has been published in final form at []. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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