| Title: | A Prospective Observational Study on Effect of Short-Term Periodic Steroid Premedication on Bone Metabolism in Gastrointestinal Cancer (ESPRESSO-01) |
| Authors: | Nakamura, Michio Browse this author |
| Ishiguro, Atsushi Browse this author |
| Muranaka, Tetsuhito Browse this author |
| Fukushima, Hiraku Browse this author |
| Yuki, Satoshi Browse this author |
| Ono, Kota Browse this author →KAKEN DB |
| Murai, Taichi Browse this author |
| Matsuda, Chika Browse this author |
| Oba, Ayane Browse this author |
| Itaya, Kazufumi Browse this author |
| Sone, Takayuki Browse this author |
| Yagisawa, Masataka Browse this author |
| Koike, Yuta Browse this author |
| Endo, Ayana Browse this author |
| Tsukuda, Yoko Browse this author |
| Ono, Yuji Browse this author |
| Kudo, Takahiko Browse this author |
| Nagasaka, Atsushi Browse this author |
| Nishikawa, Shuji Browse this author |
| Komatsu, Yoshito Browse this author →KAKEN DB |
| Keywords: | bone alkaline phosphatase |
| bone mineral density |
| chemotherapy |
| gastrointestinal cancer |
| steroid-induced osteoporosis |
| glucocorticoid premedication |
| Issue Date: | May-2017 |
| Publisher: | AlphaMed Press |
| Journal Title: | The Oncologist |
| Volume: | 22 |
| Issue: | 5 |
| Start Page: | 592 |
| End Page: | 600 |
| Publisher DOI: | 10.1634/theoncologist.2016-0308 |
| Abstract: | Background. A multicenter prospective observational study evaluated the effect of gastrointestinal cancer chemotherapy with short‐term periodic steroid premedication on bone metabolism. Patients and Methods. Seventy‐four patients undergoing chemotherapy for gastrointestinal cancer were studied. The primary endpoints were changes in bone mineral densities (BMDs) and metabolic bone turnover 16 weeks after initiation of chemotherapy. BMDs, measured by dual‐energy x‐ray absorptiometry, and serum cross‐linked N‐telopeptides of type I collagen (sNTX), and bone alkaline phosphatase (sBAP) were assessed for evaluation of bone resorption and formation, respectively. Results. In 74.3% (55/74) of the patients, BMDs were significantly reduced at 16 weeks relative to baseline. The percent changes of BMD were -1.89% (95% confidence interval [CI], -2.67% to -1.11%: p < .0001) in the lumbar spine, -2.24% (95% CI, -3.59% to -0.89%: p = .002) in the total hip, and -2.05% (95% CI, -3.11% to -0.99%: p < .0001) in the femoral neck. Although there was no significant difference in sNTX levels during 16 weeks (p = .136), there was a significant increase in sBAP levels (p = .010). Decreased BMD was significantly linked to number of chemotherapy cycles (p = .02). There were no significant correlations between changes in BMDs and the primary site of malignancy, chemotherapy regimens, total cumulative steroid dose, steroid dose intensity, and additive steroid usage. Conclusion. Gastrointestinal cancer chemotherapy with periodic glucocorticoid premedication was associated with reduced BMD and increased sBAP levels, which were linked to number of chemotherapy cycles but independent of primary site, chemotherapy regimen, duration, and additive steroid usage. |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/66646 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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