HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences >
Peer-reviewed Journal Articles, etc >

The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice

Files in This Item:
Miyashita FF.pdf451.16 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/66766

Title: The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice
Authors: Yamauchi, Ippei Browse this author
Uemura, Mariko Browse this author
Hosokawa, Masashi Browse this author →KAKEN DB
Iwashima-Suzuki, Ai Browse this author
Shiota, Makoto Browse this author
Miyashita, Kazuo Browse this author →KAKEN DB
Issue Date: 26-Jul-2016
Publisher: Royal Society of Chemistry
Journal Title: Food & function
Volume: 7
Issue: 9
Start Page: 3854
End Page: 3867
Publisher DOI: 10.1039/c6fo00274a
PMID: 27501823
Abstract: Purified milk sphingomyelin (SM) was obtained from lipid concentrated butter serum (LC-BS) by successive separations involving solvent fractionation, selective saponification, and silicic acid column chromatography. The SM obtained was given to obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice. SM supplementation significantly increased fecal lipids paralleled with a decrease in non-HDL cholesterol levels in the serum and neutral lipids and in cholesterol levels in the livers of KK-A(y) mice. The reduction of liver lipid levels also resulted in a decrease in the total fatty acid content of the KK-A(y) mice livers, while n-3 fatty acids derived from the conversion of a-linolenic acid (18:3n-3) increased due to SM supplementation. In contrast to the KK-A(y) mice, little change in the serum and liver lipids was observed in wild-type C57BL/6J mice. The present study suggests that SM may be effective only in subjects with metabolic disorders.
Type: article (author version)
URI: http://hdl.handle.net/2115/66766
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮下 和夫

Export metadata:

OAI-PMH ( junii2 , jpcoar )


 

Feedback - Hokkaido University