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Hokkaido University Collection of Scholarly and Academic Papers >
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The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice
| Title: | The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice |
| Authors: | Yamauchi, Ippei Browse this author | | Uemura, Mariko Browse this author | | Hosokawa, Masashi Browse this author →KAKEN DB | | Iwashima-Suzuki, Ai Browse this author | | Shiota, Makoto Browse this author | | Miyashita, Kazuo Browse this author →KAKEN DB |
| Issue Date: | 26-Jul-2016 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | Food & function |
| Volume: | 7 |
| Issue: | 9 |
| Start Page: | 3854 |
| End Page: | 3867 |
| Publisher DOI: | 10.1039/c6fo00274a |
| PMID: | 27501823 |
| Abstract: | Purified milk sphingomyelin (SM) was obtained from lipid concentrated butter serum (LC-BS) by successive separations involving solvent fractionation, selective saponification, and silicic acid column chromatography. The SM obtained was given to obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice. SM supplementation significantly increased fecal lipids paralleled with a decrease in non-HDL cholesterol levels in the serum and neutral lipids and in cholesterol levels in the livers of KK-A(y) mice. The reduction of liver lipid levels also resulted in a decrease in the total fatty acid content of the KK-A(y) mice livers, while n-3 fatty acids derived from the conversion of a-linolenic acid (18:3n-3) increased due to SM supplementation. In contrast to the KK-A(y) mice, little change in the serum and liver lipids was observed in wild-type C57BL/6J mice. The present study suggests that SM may be effective only in subjects with metabolic disorders. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/66766 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮下 和夫
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