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Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

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Title: Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study
Authors: Adachi, Yasushi Browse this author
Nojima, Masanori Browse this author
Mori, Mitsuru Browse this author →KAKEN DB
Yamashita, Kentaro Browse this author
Yamano, Hiro-o Browse this author
Nakase, Hiroshi Browse this author
Endo, Takao Browse this author
Wakai, Kenji Browse this author →KAKEN DB
Sakata, Kiyomi Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Esophageal cancer
Insulin-like growth factor
Insulin-like growth factor binding protein
Nested case-control study
Odds ratio
Issue Date: 21-May-2017
Publisher: Baishideng Publishing Group
Journal Title: World Journal of Gastroenterology
Volume: 23
Issue: 19
Start Page: 3488
End Page: 3495
Publisher DOI: 10.3748/wjg.v23.i19.3488
Abstract: AIM: To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal carcinoma. METHODS: We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels. RESULTS: Thirty-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95% CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150). CONCLUSION: The free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence.
Rights: licenses/by-nc/4.0/
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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