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p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex

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Title: p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex
Authors: Anwar, Delnur Browse this author
Takahashi, Hidehisa Browse this author →KAKEN DB
Watanabe, Masashi Browse this author
Suzuki, Masanobu Browse this author
Fukuda, Satoshi Browse this author →KAKEN DB
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: p53
ELL
Transcription
snRNA
LEC
Issue Date: Aug-2016
Publisher: Elsevier
Journal Title: Biochimica et biophysica acta. Gene regulatory mechanisms
Volume: 1859
Issue: 8
Start Page: 975
End Page: 982
Publisher DOI: 10.1016/j.bbagrm.2016.06.001
PMID: 27268141
Abstract: The regulation of transcription by RNA polymerase II (Pol II) is important for a variety of cellular functions. ELL/EAF-containing little elongation complex (LEC) was found to be required for transcription of Pol II-dependent small nuclear RNA (snRNA) genes. It was shown that the tumor suppressor p53 interacts with ELL and inhibits transcription elongation activity of ELL Here, we show that p53 inhibits interaction between ELL/EAF and ICE1 in LEC and thereby p53 represses transcription of Pol II-dependent snRNA genes through inhibiting LEC function. Furthermore, induction of p53 expression by ultraviolet (UV) irradiation decreases the occupancy of ICE1 at Pol II-dependent snRNA genes. Consistent with the results, knockdown of p53 increased both the expression of snRNA genes and the occupancy of Pol II and components of LEC at snRNA genes. Our results indicate that p53 interferes with the interaction between ELL/EAF and ICE1 and represses transcription of snRNA genes by Pol II.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/66903
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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