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Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet

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Title: Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet
Authors: Lee, Yeonmi Browse this author
Yoshitsugu, Reika Browse this author
Kikuchi, Keidai Browse this author
Joe, Ga-Hyun Browse this author
Tsuji, Misaki Browse this author
Nose, Takuma Browse this author
Shimizu, Hidehisa Browse this author
Hara, Hiroshi Browse this author →KAKEN DB
Minamida, Kimiko Browse this author
Miwa, Kazunori Browse this author
Ishizuka, Satoshi Browse this author →KAKEN DB
Keywords: Bile acids
Soya pulp
Bacillus coagulans lilac-01
Synbiotics
Gut permeability
Issue Date: Aug-2016
Publisher: Cambridge University Press
Journal Title: British journal of nutrition
Volume: 116
Issue: 4
Start Page: 603
End Page: 610
Publisher DOI: 10.1017/S0007114516002270
PMID: 27464459
Abstract: Intestinal bacteria are involved in bile acid (BA) deconjugation and/ or dehydroxylation and are responsible for the production of secondary BA. However, an increase in the production of secondary BA modulates the intestinal microbiota due to the bactericidal effects and promotes cancer risk in the liver and colon. The ingestion of Bacillus coagulans improves constipation via the activation of bowel movement to promote defaecation in humans, which may alter BA metabolism in the intestinal contents. BA secretion is promoted with high-fat diet consumption, and the ratio of cholic acid (CA): chenodeoxycholic acid in primary BA increases with ageing. The dietary supplementation of CA mimics the BA environment in diet-induced obesity and ageing. We investigated whether B. coagulans lilac-01 and soya pulp influence both BA metabolism and the maintenance of host health in CA-supplemented diet-fed rats. In CA-fed rats, soya pulp significantly increased the production of secondary BA such as deoxycholic acid and omega-muricholic acids, and soya pulp ingestion alleviated problems related to plasma adiponectin and gut permeability in rats fed the CA diet. The combination of B. coagulans and soya pulp successfully suppressed the increased production of secondary BA in CA-fed rats compared with soya pulp itself, without impairing the beneficial effects of soya pulp ingestion. In conclusion, it is possible that a combination of prebiotics and probiotics can be used to avoid an unnecessary increase in the production of secondary BA in the large intestine without impairing the beneficial functions of prebiotics.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/66932
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 敏

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