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Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice

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Title: Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice
Authors: Yamashita, Maya Browse this author
Matsumoto, Kurumi Browse this author
Endo, Tsutomu Browse this author
Ukibe, Ken Browse this author
Hosoya, Tomohiro Browse this author
Matsubara, Yumi Browse this author
Nakagawa, Hisako Browse this author
Sakai, Fumihiko Browse this author
Miyazaki, Tadaaki Browse this author →KAKEN DB
Keywords: Lactobacillus helveticus SBT2171
rheumatoid arthritis
collagen-induced arthritis
autoantibody production
pro-inflammatory cytokines
Issue Date: 21-Jun-2017
Publisher: Frontiers Media
Journal Title: Frontiers in microbiology
Volume: 8
Start Page: 1159
Publisher DOI: 10.3389/fmicb.2017.01159
Abstract: We recently reported that the intraperitoneal inoculation of Lactobacillus helveticus SBT2171 inhibited the development of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA). In the present study, we evaluated the effect of the oral administration of L. helveticus SBT2171 on CIA development and on the regulation of antigen-specific antibody production and inflammatory immune cells, which have been implicated in the development of RA. Both oral administration and intraperitoneal inoculation of L. helveticus SBT2171 reduced joint swelling, body weight loss, and the serum level of bovine type II collagen (CII)-specific antibodies in the CIA mouse model. The intraperitoneal inoculation also decreased the arthritis incidence, joint damage, and serum level of interleukin (IL)-6. In addition, the numbers of total immune cells, total B cells, germinal center B cells, and CD4+ T cells in the draining lymph nodes were decreased following intraperitoneal inoculation of L. helveticus SBT2171. These findings demonstrate the ability of L. helveticus SBT2171 to downregulate the abundance of immune cells and the subsequent production of CII-specific antibodies and IL-6, thereby suppressing the CIA symptoms, indicating its potential for use in the prevention of RA.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/66984
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮崎 忠昭

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