| Title: | Type XVII collagen coordinates proliferation in the interfollicular epidermis |
| Authors: | Watanabe, Mika Browse this author |
| Natsuga, Ken Browse this author →KAKEN DB |
| Nishie, Wataru Browse this author →KAKEN DB |
| Kobayashi, Yasuaki Browse this author |
| Donati, Giacomo Browse this author |
| Suzuki, Shotaro Browse this author |
| Fujimura, Yu Browse this author |
| Tsukiyama, Tadasuke Browse this author →KAKEN DB |
| Ujiie, Hideyuki Browse this author →KAKEN DB |
| Shinkuma, Satoru Browse this author →KAKEN DB |
| Nakamura, Hideki Browse this author →KAKEN DB |
| Murakami, Masamoto Browse this author |
| Ozaki, Michitaka Browse this author →KAKEN DB |
| Nagayama, Masaharu Browse this author →KAKEN DB |
| Watt, Fiona M Browse this author |
| Shimizu, Hiroshi Browse this author →KAKEN DB |
| Issue Date: | 11-Jul-2017 |
| Publisher: | eLife Sciences Publications |
| Journal Title: | Elife |
| Volume: | 6 |
| Start Page: | e26635 |
| Publisher DOI: | 10.7554/eLife.26635 |
| Abstract: | Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling. Physical aging abolishes membranous COL17 in IFE basal cells because of inactive atypical protein kinase C signaling and also induces epidermal hyperproliferation. The overexpression of human COL17 in aged mouse epidermis suppresses IFE hypertrophy. These findings demonstrate that COL17 governs IFE proliferation of neonatal and aged skin in distinct ways. Our study indicates that COL17 could be an important target of anti-aging strategies in the skin. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/67060 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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