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In vivo cartilage regeneration induced by a double-network hydrogel : Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model

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Title: In vivo cartilage regeneration induced by a double-network hydrogel : Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model
Authors: Kitamura, Nobuto Browse this author →KAKEN DB
Yokota, Masashi Browse this author
Kurokawa, Takayuki Browse this author →KAKEN DB
Gong, Jian Ping Browse this author →KAKEN DB
Yasuda, Kazunori Browse this author →KAKEN DB
Keywords: Cartilage repair
Double-network hydrogel
Polymer, In vivo
Sheep model
Issue Date: Sep-2016
Publisher: Wiley
Journal Title: Journal of biomedical materials research. part A
Volume: 104
Issue: 9
Start Page: 2159
End Page: 2165
Publisher DOI: 10.1002/jbm.a.35745
PMID: 27087198
Abstract: The purpose of this study was to establish the efficacy of a therapeutic strategy for an articular cartilage defect using a PAMPS/PDMAAm DN gel in a sheep model. Seventeen mature sheep were used in this study. We created a 6.0-mm osteochondral defect in the femoral trochlea of the patellofemoral (PF) joint and the medial condyle of the tibiofemoral (TF) joint. A cylindrical DN gel plug was implanted into the defect of the right knee so that a vacant space of the planned depths of 2.0 mm in Group I, 3.0 mm in Group II, and 4.0 mm in Group III were left. In the left knee, we created a defect with the same depth as the right knee. The regenerated tissues were evaluated with the O'Driscoll score and real time PCR analysis of the cartilage marker genes at 12 weeks. The DN-gel implanted defect of Group II in the PF and TF joints was completely filled with a sufficient volume of the proteoglycan-rich tissue stained with Safranin-O. The score showed that Group II was significantly greater than Groups I and III when treated with DN gel in the PF joint (p=0.0441, p=0.0174, respectively) and in the TF joint (p=0.0019, p=0.0006, respectively). This study has clarified the short-term efficacy of the cartilage regeneration strategy using the DN gel in a sheep model.
Rights: This is the peer reviewed version of the following article: Kitamura N, Yokota M, Kurokawa T, Gong JP, Yasuda K. 2016. In vivo cartilage regeneration induced by a double-network hydrogel: Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model. J Biomed Mater Res Part A 2016:104A:2159–2165., which has been published in final form at http://dx.doi.org/10.1002/jbm.a.35745. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/67079
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 北村 信人

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