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In vivo cartilage regeneration induced by a double-network hydrogel : Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/67079

タイトル: In vivo cartilage regeneration induced by a double-network hydrogel : Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model
著者: Kitamura, Nobuto 著作を一覧する
Yokota, Masashi 著作を一覧する
Kurokawa, Takayuki 著作を一覧する
Gong, Jian Ping 著作を一覧する
Yasuda, Kazunori 著作を一覧する
キーワード: Cartilage repair
Double-network hydrogel
Polymer, In vivo
Sheep model
発行日: 2016年 9月
出版者: Wiley
誌名: Journal of biomedical materials research. part A
巻: 104
号: 9
開始ページ: 2159
終了ページ: 2165
出版社 DOI: 10.1002/jbm.a.35745
抄録: The purpose of this study was to establish the efficacy of a therapeutic strategy for an articular cartilage defect using a PAMPS/PDMAAm DN gel in a sheep model. Seventeen mature sheep were used in this study. We created a 6.0-mm osteochondral defect in the femoral trochlea of the patellofemoral (PF) joint and the medial condyle of the tibiofemoral (TF) joint. A cylindrical DN gel plug was implanted into the defect of the right knee so that a vacant space of the planned depths of 2.0 mm in Group I, 3.0 mm in Group II, and 4.0 mm in Group III were left. In the left knee, we created a defect with the same depth as the right knee. The regenerated tissues were evaluated with the O'Driscoll score and real time PCR analysis of the cartilage marker genes at 12 weeks. The DN-gel implanted defect of Group II in the PF and TF joints was completely filled with a sufficient volume of the proteoglycan-rich tissue stained with Safranin-O. The score showed that Group II was significantly greater than Groups I and III when treated with DN gel in the PF joint (p=0.0441, p=0.0174, respectively) and in the TF joint (p=0.0019, p=0.0006, respectively). This study has clarified the short-term efficacy of the cartilage regeneration strategy using the DN gel in a sheep model.
Rights: This is the peer reviewed version of the following article: Kitamura N, Yokota M, Kurokawa T, Gong JP, Yasuda K. 2016. In vivo cartilage regeneration induced by a double-network hydrogel: Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model. J Biomed Mater Res Part A 2016:104A:2159–2165., which has been published in final form at http://dx.doi.org/10.1002/jbm.a.35745. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/67079
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 北村 信人

 

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