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Variation in the coat-color-controlling genes, Mc1r and Asip,in the house mouse Mus musculus from Madagascar

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Title: Variation in the coat-color-controlling genes, Mc1r and Asip,in the house mouse Mus musculus from Madagascar
Authors: Sakuma, Yuki Browse this author
Ranorosoa, Marie C. Browse this author
Kinoshita, Gohta Browse this author
Shimoji, Hiroyuki Browse this author
Tsuchiya, Kimiyuki Browse this author
Ohdachi, Satoshi D. Browse this author →KAKEN DB
Arai, Satoru Browse this author
Tanaka, Chihiro Browse this author
Ramino, Hajanirina Browse this author
Suzuki, Hitoshi Browse this author
Issue Date: 1-Sep-2016
Publisher: The Mammal Society of Japan
Journal Title: Mammal Study
Volume: 41
Issue: 3
Start Page: 131
End Page: 140
Publisher DOI: 10.3106/041.041.0303
Abstract: Variability in the coat color of the house mouse, Mus musculus, provides an opportunity to study the evolution of phenotypes in this species. Here we associated genetic variations with coat color in seven mice from Madagascar that had identical M. m. gentilulus mitochondrial DNA sequences. The entire coding region of the 948-base pair (bp) coat-color-related gene, Mc1r, was shown to have no nonsynonymous changes. However, analyses of the two exon-1 promoter regions—termed 1A (317 bp) and 1B (499 bp)—from a second gene, Asip, which is also involved in the evolution of coat color, revealed two distinct haplotypes in each region. Associations between Asip promoter regions and dorsal color were ambiguous; however, two ventral color types—light and dark gray—were associated with the haplotypes of 1A, as determined by clustering analysis. Notably, the haplotype of the light gray animals was identical to the Asip Aw allele that is associated with white bellies.
Type: article
Appears in Collections:低温科学研究所 (Institute of Low Temperature Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大舘 智志

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