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Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam

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Title: Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam
Authors: Duc-Huy Chu Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Matsuno, Keita Browse this author →KAKEN DB
Hiono, Takahiro Browse this author
Ogasawara, Kohei Browse this author
Lam Thanh Nguyen Browse this author
Long Van Nguyen Browse this author
Tien Ngoc Nguyen Browse this author
Thuy Thu Nguyen Browse this author
Dong Van Pham Browse this author
Dang Hoang Nguyen Browse this author
Tho Dang Nguyen Browse this author
Thanh Long To Browse this author
Hung Van Nguyen Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: Avian influenza
Antigenic analysis
Phylogenetic analysis
Live bird market
Surveillance
Issue Date: 31-Aug-2016
Publisher: Elsevier
Journal Title: Veterinary Microbiology
Volume: 192
Start Page: 194
End Page: 203
Publisher DOI: 10.1016/j.vetmic.2016.07.016
PMID: 27527783
Abstract: A total of 3,045 environmental samples and oropharyngeal and cloacal swabs from apparently healthy poultry have been collected at three live bird markets (LBMs) at which practices were applied to reduce avian influenza (AI) virus transmission (intervention LBMs) and six conventional LBMs (non-intervention LBMs) in Thua Thien Hue province in 2014 to evaluate the efficacy of the intervention LBMs. The 178 AI viruses, including H3 (19 viruses), H4 (2), H5 (8), H6 (30), H9 (114), and H11 (5), were isolated from domestic ducks, muscovy ducks, chickens, and the environment. The prevalence of AI viruses in intervention LBMs (6.1%; 95% CI: 5.0-7.5) was similar to that in non-intervention LBMs (5.6%; 95% CI: 4.5-6.8; x(2) = 0.532; df = 1; P = 0.53) in the study area. Eight H5N6 highly pathogenic avian influenza (HPAI) viruses were isolated from apparently healthy ducks, muscovy ducks, and an environmental sample in an intervention LBM. The hemagglutinin genes of the H5N6 HPAI viruses belonged to the genetic Glade 23.4.4, and the antigenicity of the H5N6 HPAI viruses differed from the H5N1 HPAI viruses previously circulating in Vietnam. Phylogenetic and antigenic analyses of the H6 and H9 viruses isolated in both types of LBMs revealed that they were closely related to the viruses isolated from domestic birds in China, Group II of H6 viruses and Y280 lineage of H9 viruses. These results indicate that the interventions currently applied in LBMs are insufficient to control AI. A risk analysis should be conducted to identify the key factors contributing to Al virus prevalence in intervention LBMs. (C) 2016 Elsevier B.V. All rights reserved.
Rights: ©2016, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/67102
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

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