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Cerebellar Roles in Self-Timing for Sub- and Supra-Second Intervals

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Title: Cerebellar Roles in Self-Timing for Sub- and Supra-Second Intervals
Authors: Ohmae, Shogo Browse this author
Kunimatsu, Jun Browse this author →KAKEN DB
Tanaka, Masaki Browse this author →KAKEN DB
Keywords: cognitive function
extracellular recording
internal time
time reproduction
Issue Date: 29-Mar-2017
Publisher: Society for Neuroscience
Journal Title: The Journal of Neuroscience
Volume: 37
Issue: 13
Start Page: 3511
End Page: 3522
Publisher DOI: 10.1523/JNEUROSCI.2221-16.2017
PMID: 28242799
Abstract: Previous studies suggest that the cerebellum and basal ganglia are involved in sub-second and supra-second timing, respectively. To test this hypothesis at the cellular level, we examined the activity of single neurons in the cerebellar dentate nucleus in monkeys performing the oculomotor version of the self-timing task. Animals were trained to report the passage of time of 400, 600, 1200, or 2400 ms following a visual cue by making self-initiated memory-guided saccades. We found a sizeable preparatory neuronal activity before self-timed saccades across delay intervals, while the time course of activity correlated with the trial-by-trial variation of saccade latency in different ways depending on the length of the delay intervals. For the shorter delay intervals, the ramping up of neuronal firing rate started just after the visual cue and the rate of rise of neuronal activity correlated with saccade timing. In contrast, for the longest delay (2400 ms), the preparatory activity started late during the delay period, and its onset time correlated with self-timed saccade latency. Because electrical microstimulation applied to the recording sites during saccade preparation advanced self-timed but not reactive saccades, regardless of their directions, the signals in the cerebellum may have a causal role in self-timing. We suggest that the cerebellum may regulate timing in both sub-second and supra-second ranges, although its relative contribution might be greater for sub-second than for supra-second time intervals.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 真樹

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