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Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study

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Title: Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study
Authors: Kobayashi, Sumitaka Browse this author →KAKEN DB
Sata, Fumihiro Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Braimoh, Titilola Serifat Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Kobayashi, Sachiko Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Maternal smoking
Aromatic hydrocarbon receptor (AHR)
Cytochrome P450 1A1 (CYP1A1)
X-ray–complementing gene 1 (XRCC1)
Birth size
Issue Date: Oct-2016
Publisher: Elsevier
Journal Title: Reproductive Toxicology
Volume: 65
Start Page: 295
End Page: 306
Publisher DOI: 10.1016/j.reprotox.2016.08.020
PMID: 27592400
Abstract: Objectives: We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size. Methods: Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off = 11.48 ng/mL). We conducted data analysis using multiple linear regression models. Results: Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed, -145 g less than those born of mothers who did not smoke and had the AHR-GA/AA, CYP1A1-AA, and XRCC1-CC genotypes (95% CI: -241, -50). Conclusions: We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/67220
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 澄貴

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