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Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma

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Title: Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma
Other Titles: Renal function and oropharyngeal cancer
Authors: Homma, Akihiro Browse this author →KAKEN DB
Hayashi, Ryuichi Browse this author
Kawabata, Kazuyoshi Browse this author
Fujii, Takashi Browse this author
Iwae, Shigemichi Browse this author
Hasegawa, Yasuhisa Browse this author →KAKEN DB
Nibu, Kenichi Browse this author
Kato, Takakuni Browse this author →KAKEN DB
Shiga, Kiyoto Browse this author →KAKEN DB
Matsuura, Kazuto Browse this author →KAKEN DB
Monden, Nobuya Browse this author
Fujii, Masato Browse this author →KAKEN DB
Keywords: oropharyngeal cancer
squamous cell carcinoma
prognosis
renal function
comorbidity
Issue Date: Oct-2016
Publisher: Wiley
Journal Title: Head & neck
Volume: 38
Issue: 10
Start Page: 1495
End Page: 1500
Publisher DOI: 10.1002/hed.24467
PMID: 27044005
Abstract: BACKGROUND: Renal function influences decisions regarding treatment for patients with squamous cell carcinoma of the oropharynx (SCC-OP). However, the importance of renal function in SCC-OP has not yet been reported. METHODS: Four hundred and sixty patients with SCC-OP treated with curative intent between April 2005 and March 2007 in 12 institutions in Japan were analyzed retrospectively. RESULTS: Four hundred and three patients (87.6%) showed a Ccr ≥50 mL/min and 57 (12.4%) a Ccr <50 mL/min. Age was associated with worse overall survival (OS), while stage IVB, radiotherapy, and Ccr<50 were associated with worse OS on univariate analyses. Surgery and hypertension were associated with better OS on univariate analyses. On multivariate analysis, age, stage, hypertension, and Ccr were also found to be significantly associated with OS. CONCLUSIONS: Based on this retrospective study, impaired renal function is an independent predictor of increased risk of death in patients with SCC-OP.
Rights: This is the peer reviewed version of the following article: Homma, A., Hayashi, R., Kawabata, K., Fujii, T., Iwae, S., Hasegawa, Y., Nibu, K., Kato, T., Shiga, K., Matsuura, K., Monden, N. and Fujii, M. (2016), Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma. Head Neck, 38: 1495–1500, which has been published in final form at http://dx.doi.org/10.1002/hed.24467. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/67223
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 本間 明宏

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