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Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis

EurArchOtoRhinoLaryn273_3331.pdf1.41 MBPDF見る/開く

タイトル: Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis
著者: Suzuki, Takayoshi 著作を一覧する
Sakashita, Tomohiro 著作を一覧する
Homma, Akihiro 著作を一覧する
Hatakeyama, Hiromitsu 著作を一覧する
Kano, Satoshi 著作を一覧する
Mizumachi, Takatsugu 著作を一覧する
Yoshida, Daisuke 著作を一覧する
Fujima, Noriyuki 著作を一覧する
Onimaru, Rikiya 著作を一覧する
Tsuchiya, Kazuhiko 著作を一覧する
Yasuda, Koichi 著作を一覧する
Shirato, Hiroki 著作を一覧する
Suzuki, Fumiyuki 著作を一覧する
Fukuda, Satoshi 著作を一覧する
キーワード: Intra-arterial
Retropharyngeal lymph node
Ascending pharyngeal artery
発行日: 2016年10月
出版者: Springer
誌名: European Archives of Oto-Rhino-Laryngology
巻: 273
号: 10
開始ページ: 3331
終了ページ: 3336
出版社 DOI: 10.1007/s00405-016-3933-5
抄録: Objective: We sought to evaluate the efficacy and feasibility of superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (hereafter RADPLAT) for head and neck squamous cell cancer (hereafter HNSCC) patients with retropharyngeal lymph node (hereafter RPLN) metastasis. Study Design: Retrospective case series review. Setting: University medical center in Japan. Subjects and Methods: Ten HNSCC patients with RPLN metastasis treated by RADPLAT were analyzed. Results: The ascending pharyngeal artery was targeted for the treatment of RPLN metastasis in 9 patients. The median total dose of cisplatin was 26.6 mg/m2 (mean, 31.5 mg/m2; range, 11.7-87.9 mg/m2). In the remaining patient, the RPLN was supplied by the ascending palatine artery. As grade 3 and 4 adverse effects, leukopenia was observed in three, mucositis in four and nausea in one patient. No neurological complications were observed in any patients. Metastatic RPLNs were evaluated as a complete response in all patients. There was no recurrence of RPLN metastasis in any patients. Four patients remain alive without any evidence of disease and six patients died of disease. The 5-year overall survival rate was 50%. Conclusions: We have shown that superselective intra-arterial cisplatin infusion for RPLNs was a feasible and effective approach for HNSCC patients with RPLN metastasis.
Rights: The final publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 本間 明宏


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