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Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

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Title: Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure
Authors: Furihata, Takaaki Browse this author →KAKEN DB
Kinugawa, Shintaro Browse this author →KAKEN DB
Fukushima, Arata Browse this author →KAKEN DB
Takada, Shingo Browse this author →KAKEN DB
Homma, Tsuneaki Browse this author
Masaki, Yoshihiro Browse this author
Abe, Takahiro Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Oba, Koji Browse this author →KAKEN DB
Okita, Koichi Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: Heart failure
Myostatin
Muscle wasting
Issue Date: 1-Oct-2016
Publisher: Elsevier
Journal Title: International journal of cardiology
Volume: 220
Start Page: 483
End Page: 487
Publisher DOI: 10.1016/j.ijcard.2016.06.231
PMID: 27390974
Abstract: Background: It has been reported that skeletal muscle mass and strength are decreased in patients with heart failure (HF), and HF is associated with both reduced exercise capacity and adverse clinical outcomes. Myostatin has been known as a negative regulator of muscle growth, follistatin as the myostatin antagonist, maintaining tissue homeostasis. We thus determined serum myostatin levels in HF patients and whether they are associated with skeletal muscle wasting. Methods and results: Forty one consecutive HF patients (58 +/- 15 years old, New York Heart Association class I-III) and 30 age-matched healthy subjects as controls (53 +/- 8 years old) were studied. Serum myostatin levels were significantly lower in HF patients than controls (18.7 +/- 7.4 vs. 23.6 +/- 5.2 ng/mL, P < 0.001). Circumference of the thickest part of the right thigh was significantly small (468 +/- 72 vs. 559 +/- 37 mm, P = 0.001) and lower extremity muscular strength was lower in patients with HF (129 +/- 55 vs. 219 +/- 52 N × m, P < 0.001). Fourteen HF patients (34%) had muscle wasting. By univariate analysis, higher age, higher serum follistatin, and lower serum myostatin were significantly associated with the presence of muscle wasting. By multivariate analysis, serum myostatin levels were independently associated with muscle wasting (OR = 0.77, 95% CI [0.58, 0.93], P = 0.02). Conclusion: Serum myostatin levels were significantly decreased in HF patients and associated with lower extremity muscle wasting, suggesting that myostatin may be an important factor for maintaining skeletal muscle mass and strength in HF.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/67234
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 降旗 高明

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