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Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure


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タイトル: Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure
著者: Furihata, Takaaki 著作を一覧する
Kinugawa, Shintaro 著作を一覧する
Fukushima, Arata 著作を一覧する
Takada, Shingo 著作を一覧する
Homma, Tsuneaki 著作を一覧する
Masaki, Yoshihiro 著作を一覧する
Abe, Takahiro 著作を一覧する
Yokota, Takashi 著作を一覧する
Oba, Koji 著作を一覧する
Okita, Koichi 著作を一覧する
Tsutsui, Hiroyuki 著作を一覧する
キーワード: Heart failure
Muscle wasting
発行日: 2016年10月 1日
出版者: Elsevier
誌名: International journal of cardiology
巻: 220
開始ページ: 483
終了ページ: 487
出版社 DOI: 10.1016/j.ijcard.2016.06.231
抄録: Background: It has been reported that skeletal muscle mass and strength are decreased in patients with heart failure (HF), and HF is associated with both reduced exercise capacity and adverse clinical outcomes. Myostatin has been known as a negative regulator of muscle growth, follistatin as the myostatin antagonist, maintaining tissue homeostasis. We thus determined serum myostatin levels in HF patients and whether they are associated with skeletal muscle wasting. Methods and results: Forty one consecutive HF patients (58 +/- 15 years old, New York Heart Association class I-III) and 30 age-matched healthy subjects as controls (53 +/- 8 years old) were studied. Serum myostatin levels were significantly lower in HF patients than controls (18.7 +/- 7.4 vs. 23.6 +/- 5.2 ng/mL, P < 0.001). Circumference of the thickest part of the right thigh was significantly small (468 +/- 72 vs. 559 +/- 37 mm, P = 0.001) and lower extremity muscular strength was lower in patients with HF (129 +/- 55 vs. 219 +/- 52 N × m, P < 0.001). Fourteen HF patients (34%) had muscle wasting. By univariate analysis, higher age, higher serum follistatin, and lower serum myostatin were significantly associated with the presence of muscle wasting. By multivariate analysis, serum myostatin levels were independently associated with muscle wasting (OR = 0.77, 95% CI [0.58, 0.93], P = 0.02). Conclusion: Serum myostatin levels were significantly decreased in HF patients and associated with lower extremity muscle wasting, suggesting that myostatin may be an important factor for maintaining skeletal muscle mass and strength in HF.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 降旗 高明


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