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Rapid tin-mediated access to a lysophosphatidylethanolamine (LPE) library: Application to positional LC/MS analysis for hepatic LPEs in non-alcoholic steatohepatitis model mice

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/67258

タイトル: Rapid tin-mediated access to a lysophosphatidylethanolamine (LPE) library: Application to positional LC/MS analysis for hepatic LPEs in non-alcoholic steatohepatitis model mice
著者: Furukawa, Takayuki 著作を一覧する
Fuda, Hirotoshi 著作を一覧する
Miyanaga, Satoshi 著作を一覧する
Watanabe, Chinatsu 著作を一覧する
Chiba, Hitoshi 著作を一覧する
Hui, Shu-Ping 著作を一覧する
キーワード: Lysophosphatidylethanolamine
Tin
Regioisomer
Non-alcoholic steatohepatitis
LC/MS
発行日: 2016年10月 1日
出版者: Elsevier
誌名: Chemistry and Physics of Lipids
巻: 200
開始ページ: 133
終了ページ: 138
出版社 DOI: 10.1016/j.chemphyslip.2016.09.003
抄録: Even though lysophospholipids have attracted much interest in recent years on account of their unique bioactivity, research related to lysophospholipids is usually hampered by problems associated with standard sample preparation and discrimination of regioisomers. Herein, we demonstrate a quick tinchemistry-based synthetic route to lysophosphatidylethanolamines (LPEs) and its application in the positional analysis of hepatic LPEs in non-alcoholic steatohepatitis (NASH) model mice. We found that the preference of hepatic LPE regioisomer largely depends on the unsaturation of acyl chain in both control and NASH model mice. In addition, hepatic C18:2-LPE and C20:5-LPE levels were significantly lower in the NASH model mice than those in the control. The LC/MS technique based on the library of LPE regioisomers allows an accurate observation of hepatic LPE metabolism and might provide useful information to elucidate yet ambiguous pathogenesis of NASH.
Rights: ©2016, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/67258
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 古川 貴之

 

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