HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
北海道大学病院  >
雑誌発表論文等  >

Glucose tolerance is improved following surgery for silent somatotroph adenoma


IJDCR-2-047.pdf812.17 kBPDF見る/開く

タイトル: Glucose tolerance is improved following surgery for silent somatotroph adenoma
著者: Miya, Aika 著作を一覧する
Nakamura, Akinobu 著作を一覧する
Miyoshi, Hideaki 著作を一覧する
Kameda, Hiraku 著作を一覧する
Nomoto, Hiroshi 著作を一覧する
Nagai, So 著作を一覧する
Omori, Yuko 著作を一覧する
Hatanaka, Kanako C. 著作を一覧する
Kobayashi, Hiroyuki 著作を一覧する
Shimizu, Chikara 著作を一覧する
Atsumi, Tatsuya 著作を一覧する
キーワード: Silent somatotroph adenoma
glucose tolerance
oral glucose tolerance test
insulin sensitivity
発行日: 2015年
出版者: ClinMed International Library
誌名: International Journal of Diabetes and Clinical Research
巻: 2
号: 6
開始ページ: 047
出版社 DOI: 10.23937/2377-3634/1410047
抄録: Although the excessive secretion of GH leads to insulin resistance enhancement, the involvement of a silent somatotroph adenoma in abnormal glucose tolerance has not been elucidated. A 50 - year-old man was admitted with a headache and bitemporal hemianopia caused by a pituitary macroadenoma. He had no physical signs and symptoms of acromegaly nor hypopituitarism, and his base-line serum levels of GH and insulin - like growth factor-1 (IGF-1) were normal. However, a 75 - g oral glucose tolerance test (OGTT) showed unsuppressed GH concentrations as well as plasma glucose levels consistent with diabetes pattern. A transsphenoidal adenomectomy was performed, and we diagnosed the patient as having a silent somatotroph adenoma based on positive GH in the immunohistochemistry. Postoperative OGTT showed GH suppression and a normal pattern of plasma glucose levels after glucose loading. The post-surgery homeostasis model assessment insulin resistance index (HOMA - IR) and the Matsuda Index indicated improved insulin sensitivity in the absence of perioperative body-mass-index change. These observations suggest that reversible abnormal glucose tolerance is associated with a silent somatotroph adenoma in this patient.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 三好 秀明


本サイトに関するご意見・お問い合わせは repo at へお願いします。 - 北海道大学