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Glucose tolerance is improved following surgery for silent somatotroph adenoma

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Title: Glucose tolerance is improved following surgery for silent somatotroph adenoma
Authors: Miya, Aika Browse this author
Nakamura, Akinobu Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Kameda, Hiraku Browse this author
Nomoto, Hiroshi Browse this author
Nagai, So Browse this author →KAKEN DB
Omori, Yuko Browse this author
Hatanaka, Kanako C. Browse this author
Kobayashi, Hiroyuki Browse this author
Shimizu, Chikara Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: Silent somatotroph adenoma
glucose tolerance
oral glucose tolerance test
insulin sensitivity
Issue Date: 2015
Publisher: ClinMed International Library
Journal Title: International Journal of Diabetes and Clinical Research
Volume: 2
Issue: 6
Start Page: 047
Publisher DOI: 10.23937/2377-3634/1410047
Abstract: Although the excessive secretion of GH leads to insulin resistance enhancement, the involvement of a silent somatotroph adenoma in abnormal glucose tolerance has not been elucidated. A 50 - year-old man was admitted with a headache and bitemporal hemianopia caused by a pituitary macroadenoma. He had no physical signs and symptoms of acromegaly nor hypopituitarism, and his base-line serum levels of GH and insulin - like growth factor-1 (IGF-1) were normal. However, a 75 - g oral glucose tolerance test (OGTT) showed unsuppressed GH concentrations as well as plasma glucose levels consistent with diabetes pattern. A transsphenoidal adenomectomy was performed, and we diagnosed the patient as having a silent somatotroph adenoma based on positive GH in the immunohistochemistry. Postoperative OGTT showed GH suppression and a normal pattern of plasma glucose levels after glucose loading. The post-surgery homeostasis model assessment insulin resistance index (HOMA - IR) and the Matsuda Index indicated improved insulin sensitivity in the absence of perioperative body-mass-index change. These observations suggest that reversible abnormal glucose tolerance is associated with a silent somatotroph adenoma in this patient.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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