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Glucose tolerance is improved following surgery for silent somatotroph adenoma
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| Title: | Glucose tolerance is improved following surgery for silent somatotroph adenoma |
| Authors: | Miya, Aika Browse this author | | Nakamura, Akinobu Browse this author →KAKEN DB | | Miyoshi, Hideaki Browse this author →KAKEN DB | | Kameda, Hiraku Browse this author | | Nomoto, Hiroshi Browse this author | | Nagai, So Browse this author →KAKEN DB | | Omori, Yuko Browse this author | | Hatanaka, Kanako C. Browse this author | | Kobayashi, Hiroyuki Browse this author | | Shimizu, Chikara Browse this author →KAKEN DB | | Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | Silent somatotroph adenoma | | glucose tolerance | | oral glucose tolerance test | | insulin sensitivity |
| Issue Date: | 2015 |
| Publisher: | ClinMed International Library |
| Journal Title: | International Journal of Diabetes and Clinical Research |
| Volume: | 2 |
| Issue: | 6 |
| Start Page: | 047 |
| Publisher DOI: | 10.23937/2377-3634/1410047 |
| Abstract: | Although the excessive secretion of GH leads to insulin resistance enhancement, the involvement of a silent somatotroph adenoma in abnormal glucose tolerance has not been elucidated. A 50 - year-old man was admitted with a headache and bitemporal hemianopia caused by a pituitary macroadenoma. He had no physical signs and symptoms of acromegaly nor hypopituitarism, and his base-line serum levels of GH and insulin - like growth factor-1 (IGF-1) were normal. However, a 75 - g oral glucose tolerance test (OGTT) showed unsuppressed GH concentrations as well as plasma glucose levels consistent with diabetes pattern. A transsphenoidal adenomectomy was performed, and we diagnosed the patient as having a silent somatotroph adenoma based on positive GH in the immunohistochemistry. Postoperative OGTT showed GH suppression and a normal pattern of plasma glucose levels after glucose loading. The post-surgery homeostasis model assessment insulin resistance index (HOMA - IR) and the Matsuda Index indicated improved insulin sensitivity in the absence of perioperative body-mass-index change. These observations suggest that reversible abnormal glucose tolerance is associated with a silent somatotroph adenoma in this patient. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/67262 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 三好 秀明
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