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A caution in the use of the NAFIC scoring system as a diagnostic screening tool for nonalcoholic steatohepatitis

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/67263

Title: A caution in the use of the NAFIC scoring system as a diagnostic screening tool for nonalcoholic steatohepatitis
Authors: Nakamura, Akinobu Browse this author →KAKEN DB
Yoneda, Masato Browse this author
Sumida, Yoshio Browse this author
Miyoshi, Hideaki Browse this author →KAKEN DB
Nakajima, Atsushi Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Terauchi, Yasuo Browse this author
Keywords: Body mass index
Female
Insulin
Male
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Obesity
Sensitivity
Type IV collagen 7S
Issue Date: Oct-2014
Publisher: OMICS International
Journal Title: Journal of Gastrointestinal & Digestive System
Volume: 4
Issue: 5
Start Page: 221
Publisher DOI: 10.4172/2161-069X.1000221
Abstract: Japanese patients with nonalcoholic fatty liver disease (NAFLD) according to the presence/absence of obesity. Methods: A total of 141 Japanese patients with liver-biopsy-confirmed NAFLD were enrolled. All patients were classified as having nonalcoholic fatty liver (NAFL) or nonalcoholic steatohepatitis (NASH) on the basis of Matteoni's classification. Obesity was defined as a body mass index of ≥25. To evaluate the overall accuracy of the NAFIC and modified NAFIC scoring systems, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of these scoring systems for the diagnosis of NASH were calculated. Results: In the obese group, the sensitivity, specificity, PPV and NPV of the NAFIC scoring system for the diagnosis of NASH were 67.3%, 76.2%, 77.8% and 65.3%, respectively, while the corresponding values for the modified NAFIC scoring systems were 78.8%, 69.0%, 75.9% and 72.5%. On the other hand, in the nonobese group, the sensitivity, specificity, PPV and NPV of the NAFIC scoring system were 47.1%, 86.7%, 66.7% and 74.3%, respectively, while those of the modified NAFIC scoring system were 58.8%, 83.3%, 66.7% and 78.1%, respectively. When the patients were divided by sex, the sensitivity of the NAFIC and modified NAFIC scoring systems in the female nonobese group were 53.8% and 69.2%, respectively. However, surprisingly, in the male nonobese group, the sensitivity of both the scoring systems was only 25.0%. Conclusion: The sensitivity of both the NAFIC and modified NAFIC scoring systems for the diagnosis of NASH was lower in the male nonobese group than in all the other groups. These findings suggest that caution should be exercised in the use of the NAFIC scoring system as a diagnostic screening tool for NASH in Japanese patients with NAFLD, especially male nonobese patients.
Type: article
URI: http://hdl.handle.net/2115/67263
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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