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The role of lipid droplets in metabolic disease in rodents and humans
Title: | The role of lipid droplets in metabolic disease in rodents and humans |
Authors: | Greenberg, Andrew S. Browse this author | Coleman, Rosalind A. Browse this author | Kraemer, Fredric B. Browse this author | McManaman, James L. Browse this author | Obin, Martin S. Browse this author | Puri, Vishwajeet Browse this author | Yan, Qing-Wu Browse this author | Miyoshi, Hideaki Browse this author →KAKEN DB | Mashek, Douglas G. Browse this author |
Issue Date: | 1-Jun-2011 |
Publisher: | American Society for Clinical Investigation |
Journal Title: | The Journal of clinical investigation |
Volume: | 121 |
Issue: | 6 |
Start Page: | 2102 |
End Page: | 2110 |
Publisher DOI: | 10.1172/JCI46069 |
Abstract: | Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease. |
Type: | article |
URI: | http://hdl.handle.net/2115/67266 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 三好 秀明
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