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The role of lipid droplets in metabolic disease in rodents and humans

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Title: The role of lipid droplets in metabolic disease in rodents and humans
Authors: Greenberg, Andrew S. Browse this author
Coleman, Rosalind A. Browse this author
Kraemer, Fredric B. Browse this author
McManaman, James L. Browse this author
Obin, Martin S. Browse this author
Puri, Vishwajeet Browse this author
Yan, Qing-Wu Browse this author
Miyoshi, Hideaki Browse this author →KAKEN DB
Mashek, Douglas G. Browse this author
Issue Date: 1-Jun-2011
Publisher: American Society for Clinical Investigation
Journal Title: The Journal of clinical investigation
Volume: 121
Issue: 6
Start Page: 2102
End Page: 2110
Publisher DOI: 10.1172/JCI46069
Abstract: Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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