IgG4-related disease : why high IgG4 and fibrosis?


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/67291

Title:	IgG4-related disease : why high IgG4 and fibrosis?
Authors:	Koike, Takao Browse this author →KAKEN DB
Issue Date:	Feb-2013
Publisher:	BioMed Central
Journal Title:	Arthritis research & therapy
Volume:	15
Issue:	1
Start Page:	103
Publisher DOI:	10.1186/ar4122
Abstract:	The hallmarks of IgG4-related disease (IgG4-RD) are lymphoplasmacytic tissue infiltration with a predominance of IgG4-positive plasma cells, accompanied by fibrosis, obliterative phlebitis, dacryoadenitis, and elevated levels of IgG4. In a recent issue of Arthritis Research & Therapy, Tsuboi and colleagues demonstrated that regulatory T (Treg) cell-and T helper 2 (Th2) cell-derived cytokines contribute to the pathogenesis of Mikulicz's disease, an activation pathway that appears to be common for IgG4-RD. Additional organ-specific factors may account for the different organ involvement of IgG4-RD.
Rights:	https://creativecommons.org/licenses/by/2.0/
Type:	article
URI:	http://hdl.handle.net/2115/67291
Appears in Collections:	医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小池隆夫

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