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IgG4-related disease : why high IgG4 and fibrosis?


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タイトル: IgG4-related disease : why high IgG4 and fibrosis?
著者: Koike, Takao 著作を一覧する
発行日: 2013年 2月
出版者: BioMed Central
誌名: Arthritis research & therapy
巻: 15
号: 1
開始ページ: 103
出版社 DOI: 10.1186/ar4122
抄録: The hallmarks of IgG4-related disease (IgG4-RD) are lymphoplasmacytic tissue infiltration with a predominance of IgG4-positive plasma cells, accompanied by fibrosis, obliterative phlebitis, dacryoadenitis, and elevated levels of IgG4. In a recent issue of Arthritis Research & Therapy, Tsuboi and colleagues demonstrated that regulatory T (Treg) cell-and T helper 2 (Th2) cell-derived cytokines contribute to the pathogenesis of Mikulicz's disease, an activation pathway that appears to be common for IgG4-RD. Additional organ-specific factors may account for the different organ involvement of IgG4-RD.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 小池 隆夫


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