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Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus
Title: | Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus |
Authors: | Hoshino, Koji Browse this author | Hasegawa, Kan Browse this author | Kamiya, Haruyuki Browse this author →KAKEN DB | Morimoto, Yuji Browse this author →KAKEN DB |
Issue Date: | Jun-2017 |
Publisher: | Biomedical Research Press |
Journal Title: | Biomedical Research |
Volume: | 38 |
Issue: | 3 |
Start Page: | 183 |
End Page: | 188 |
Publisher DOI: | 10.2220/biomedres.38.183 |
PMID: | 28637953 |
Abstract: | Interleukin-1β (IL-1β) is a key molecule in the inflammatory responses elicited during infection and injury. It exerts local effects on synaptic plasticity by binding to IL-1 receptors that are expressed at high levels in the hippocampus. We examined the effects of IL-1β on synaptic plasticity in different hippocampal regions in acute mouse brain slices by measuring long-term potentiation (LTP). IL-1β (1 ng/mL) was applied for 30 min before LTP was induced with high-frequency stimulation (HFS). LTP was significantly impaired by either IL-1β application to the Schaffer collateral- CA1 synapses or the associational/commissural (A/C) fiber-CA3 synapses, which are both dependent on N-methyl-D-aspartate (NMDA) receptor activation. However, mossy fiber-CA3 LTP, which is expressed presynaptically in an NMDA-independent manner, was not impaired by IL-1β. Our results demonstrate that IL-1β exerts variable effects on LTP at different kinds of synapses, indicating that IL-1β has synapse-specific effects on hippocampal synaptic plasticity. |
Type: | article |
URI: | http://hdl.handle.net/2115/67301 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 干野 晃嗣
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