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Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus

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タイトル: Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus
著者: Hoshino, Koji 著作を一覧する
Hasegawa, Kan 著作を一覧する
Kamiya, Haruyuki 著作を一覧する
Morimoto, Yuji 著作を一覧する
発行日: 2017年 6月
出版者: Biomedical Research Press
誌名: Biomedical Research
巻: 38
号: 3
開始ページ: 183
終了ページ: 188
出版社 DOI: 10.2220/biomedres.38.183
抄録: Interleukin-1β (IL-1β) is a key molecule in the inflammatory responses elicited during infection and injury. It exerts local effects on synaptic plasticity by binding to IL-1 receptors that are expressed at high levels in the hippocampus. We examined the effects of IL-1β on synaptic plasticity in different hippocampal regions in acute mouse brain slices by measuring long-term potentiation (LTP). IL-1β (1 ng/mL) was applied for 30 min before LTP was induced with high-frequency stimulation (HFS). LTP was significantly impaired by either IL-1β application to the Schaffer collateral- CA1 synapses or the associational/commissural (A/C) fiber-CA3 synapses, which are both dependent on N-methyl-D-aspartate (NMDA) receptor activation. However, mossy fiber-CA3 LTP, which is expressed presynaptically in an NMDA-independent manner, was not impaired by IL-1β. Our results demonstrate that IL-1β exerts variable effects on LTP at different kinds of synapses, indicating that IL-1β has synapse-specific effects on hippocampal synaptic plasticity.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 干野 晃嗣


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