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Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus

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Title: Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus
Authors: Hoshino, Koji Browse this author
Hasegawa, Kan Browse this author
Kamiya, Haruyuki Browse this author →KAKEN DB
Morimoto, Yuji Browse this author →KAKEN DB
Issue Date: Jun-2017
Publisher: Biomedical Research Press
Journal Title: Biomedical Research
Volume: 38
Issue: 3
Start Page: 183
End Page: 188
Publisher DOI: 10.2220/biomedres.38.183
PMID: 28637953
Abstract: Interleukin-1β (IL-1β) is a key molecule in the inflammatory responses elicited during infection and injury. It exerts local effects on synaptic plasticity by binding to IL-1 receptors that are expressed at high levels in the hippocampus. We examined the effects of IL-1β on synaptic plasticity in different hippocampal regions in acute mouse brain slices by measuring long-term potentiation (LTP). IL-1β (1 ng/mL) was applied for 30 min before LTP was induced with high-frequency stimulation (HFS). LTP was significantly impaired by either IL-1β application to the Schaffer collateral- CA1 synapses or the associational/commissural (A/C) fiber-CA3 synapses, which are both dependent on N-methyl-D-aspartate (NMDA) receptor activation. However, mossy fiber-CA3 LTP, which is expressed presynaptically in an NMDA-independent manner, was not impaired by IL-1β. Our results demonstrate that IL-1β exerts variable effects on LTP at different kinds of synapses, indicating that IL-1β has synapse-specific effects on hippocampal synaptic plasticity.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 干野 晃嗣

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