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Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy

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Title: Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy
Authors: Okada, Kazunori Browse this author
Kaga, Sanae Browse this author
Mikami, Taisei Browse this author →KAKEN DB
Masauzi, Nobuo Browse this author
Abe, Ayumu Browse this author
Nakabachi, Masahiro Browse this author
Yokoyama, Shinobu Browse this author
Nishino, Hisao Browse this author
Ichikawa, Ayako Browse this author
Nishida, Mutsumi Browse this author →KAKEN DB
Murai, Daisuke Browse this author
Hayashi, Taichi Browse this author
Shimizu, Chikara Browse this author →KAKEN DB
Iwano, Hiroyuki Browse this author
Yamada, Satoshi Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: Hypertension
Hypertrophic cardiomyopathy
Speckle tracking echocardiography
Strain-rate waveform
Issue Date: 18-Oct-2016
Publisher: Springer
Journal Title: Heart and Vessels
Volume: 32
Issue: 5
Start Page: 591
End Page: 599
Publisher DOI: 10.1007/s00380-016-0906-y
PMID: 27757525
Abstract: We analyzed the waveform of systolic strain and strain-rate curves to find a characteristic left ventricular (LV) myocardial contraction pattern in patients with hypertrophic cardiomyopathy (HCM), and evaluated the utility of these parameters for the differentiation of HCM and LV hypertrophy secondary to hypertension (HT). From global strain and strain-rate curves in the longitudinal and circumferential directions, the time from mitral valve closure to the peak strains (T-LS and T-CS, respectively) and the peak systolic strain rates (T-LSSR and T-CSSR, respectively) were measured in 34 patients with HCM, 30 patients with HT, and 25 control subjects. The systolic strain-rate waveform was classified into 3 patterns ("V", "W", and "√" pattern). In the HCM group, T-LS was prolonged, but T-LSSR was shortened; consequently, T-LSSR/T-LS ratio was distinctly lower than in the HT and control groups. The "√" pattern of longitudinal strain-rate waveform was more frequently seen in the HCM group (74 %) than in the control (4 %) and HT (20 %) groups. Similar but less distinct results were obtained in the circumferential direction. To differentiate HCM from HT, the sensitivity and specificity of the T-LSSR/T-LS ratio <0.34 and the "√"-shaped longitudinal strain-rate waveform were 85 and 63 %, and 74 and 80 %, respectively. In conclusion, in patients with HCM, a reduced T-LSSR/T-LS ratio and a characteristic "√"-shaped waveform of LV systolic strain rate was seen, especially in the longitudinal direction. The timing and waveform analyses of systolic strain rate may be useful to distinguish between HCM and HT.
Rights: The final publication is available at Springer via
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡田 一範

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