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Cellular function of osteocytes in normal and αklotho-deficient mice

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タイトル: Cellular function of osteocytes in normal and αklotho-deficient mice
著者: Amizuka, Norio 著作を一覧する
Hasegawa, Tomoka 著作を一覧する
Yamamoto, Tomomaya 著作を一覧する
Mae, Takahito 著作を一覧する
Zixuan, Qiu 著作を一覧する
Abe, Miki 著作を一覧する
Shen, Zhao 著作を一覧する
Nagai, Tomoya 著作を一覧する
Yokoyama, Ayako 著作を一覧する
Naznin, Khadiza 著作を一覧する
Haraguchi, Mai 著作を一覧する
Yamamoto, Tsuneyuki 著作を一覧する
Freitas, Paulo Henrique Luiz de 著作を一覧する
Li, Minqi 著作を一覧する
キーワード: osteocyte
bone
αklotho
FGF23
sclerostin
発行日: 2017年 9月
出版者: 北海道歯学会
誌名: 北海道歯学雑誌
巻: 38
号: Special issue
開始ページ: 56
終了ページ: 62
抄録: During the last decade, osteocyte-derived factors i.e., sclerostin, dentin matrix protein-1, fibroblast growth factor 23 (FGF23) that reduces serum phosphate concentration by mediating FGF receptor 1c/αklotho in the kidney, have been highlighted for osteocytes’ fine-turned regulation on bone remodeling and phosphate homeostasis. Osteocytes are interconnected through gap junctions between their cytoplasmic processes, and thereby, build upon the functional syncytia, referred to as the osteocytic lacunar-canalicular system (OLCS). Osteocytes appear to communicate surrounding osteocytes and osteoblasts by means of two possible pathways of molecular transport throughout the OLCS : One is a passageway of their cytoplasmic processes, and the other is a pericellular space in the osteocytic canaliculi. The regularly-oriented OLCS in mature compact bone appears to efficiently serve for molecular transport, mechanosensing and targeted bone remodeling that would erase microdamages in bone. In a disrupted signaling state of FGF23/αklotho, serum concentration of phosphate would be markedly-elevated. Despite highly-elevated serum phosphate, αklotho -deficient mice revealed defective mineralization in bone matrix. OLCS in αklotho -deficient mice were irregularly-distributed and the connectivity of cytoplasmic processes of osteocytes was very poor, so that osteocytes did not seem to form functional syncytia. Therefore, osteocytes’function cooperated with other bone cells, rather than serum concentration of calcium/phosphate, and this seems to play a central role in maintaining bone mineralization. In this review, the biological function of the regularly-arranged OLCS in a normal state will be introduced, as well as dysfunctional osteocytes in αklotho-deficient state, using animal models.
資料タイプ: article
URI: http://hdl.handle.net/2115/67337
出現コレクション:第38巻 記念特集号

 

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