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Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus

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Title: Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
Authors: Yoshikawa, Tomoko Browse this author →KAKEN DB
Inagaki, Natsuko F. Browse this author
Takagi, Seiji Browse this author
Kuroda, Shigeru Browse this author →ORCID
Yamasaki, Miwako Browse this author →KAKEN DB
Watanabe, Masahiko Browse this author →KAKEN DB
Honma, Sato Browse this author →KAKEN DB
Honma, Ken-ichi Browse this author →KAKEN DB
Issue Date: 15-Aug-2017
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 7
Start Page: 8210
Publisher DOI: 10.1038/s41598-017-08186-5
Abstract: The circadian pacemaker in the suprachiasmatic nucleus (SCN) yields photoperiodic response to transfer seasonal information to physiology and behavior. To identify the precise location involved in photoperiodic response in the SCN, we analyzed circadian Period1 and PERIOD2 rhythms in horizontally sectioned SCN of mice exposed to a long or short day. Statistical analyses of bioluminescence images with respective luciferase reporters on pixel level enabled us to identify the distinct localization of three oscillating regions; a large open-ring-shape region, the region at the posterior end and a sharply demarcated oval region at the center of the SCN. The first two regions are the respective sites for the so-called evening and morning oscillators, and the third region is possibly a site for mediating photic signals to the former oscillators. In these regions, there are two classes of oscillating cells in which Per1 and Per2 could play differential roles in photoperiodic responses.
Type: article
Appears in Collections:脳科学研究教育センター (Research and Education Center for Brain Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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