Title: | The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes |
Authors: | Mizushima, Wataru Browse this author |
Takahashi, Hidehisa Browse this author →KAKEN DB |
Watanabe, Masashi Browse this author |
Kinugawa, Shintaro Browse this author →KAKEN DB |
Matsushima, Shouji Browse this author |
Takada, Shingo Browse this author →KAKEN DB |
Yokota, Takashi Browse this author →KAKEN DB |
Furihata, Takaaki Browse this author →KAKEN DB |
Matsumoto, Junichi Browse this author |
Tsuda, Masaya Browse this author |
Chiba, Ikuru Browse this author |
Nagashima, Shun Browse this author |
Yanagi, Shigeru Browse this author →KAKEN DB |
Matsumoto, Masaki Browse this author →KAKEN DB |
Nakayama, Keiichi I. Browse this author →KAKEN DB |
Tsutsui, Hiroyuki Browse this author →KAKEN DB |
Hatakeyama, Shigetsugu Browse this author →KAKEN DB |
Keywords: | Cardiomyocyte |
RNF207 |
Energy metabolism |
VDAC |
Heart failure |
Issue Date: | Nov-2016 |
Publisher: | Elsevier |
Journal Title: | Journal of molecular and cellular cardiology |
Volume: | 100 |
Start Page: | 43 |
End Page: | 53 |
Publisher DOI: | 10.1016/j.yjmcc.2016.09.013 |
PMID: | 27677939 |
Abstract: | A failing heart shows severe energy insufficiency, and it is presumed that this energy shortage plays a critical role in the development of cardiac dysfunction. However, little is known about the mechanisms that cause energy metabolic alterations in the failing heart. Here, we show that the novel RING-finger protein 207 (RNF207), which is specifically expressed in the heart, plays a role in cardiac energy metabolism. Depletion of RNF207 in neonatal rat cardiomyocytes (NRCs) leads to a reduced cellular concentration of adenosine triphosphate (ATP) and mitochondrial dysfunction. Consistent with this result, we observed here that the expression of RNF207 was significantly reduced in mice with common cardiac diseases including heart failure. Intriguingly, proteomic approaches revealed that RNF207 interacts with the voltage-dependent anion channel (VDAC), which is considered to be a key regulator of mitochondria function, as an RNF207-interacting protein. Our findings indicate that RNF207 is involved in ATP production by cardiomyocytes, suggesting that RNF207 plays an important role in the development of heart failure. |
Rights: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/67491 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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