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Increased blood viscosity in ischemic stroke patients with small artery occlusion measured by an electromagnetic spinning sphere viscometer
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| Title: | Increased blood viscosity in ischemic stroke patients with small artery occlusion measured by an electromagnetic spinning sphere viscometer |
| Authors: | Furukawa, Koji Browse this author | | Abumiya, Takeo Browse this author →KAKEN DB | | Sakai, Keiji Browse this author →KAKEN DB | | Hirano, Miki Browse this author | | Osanai, Toshiya Browse this author | | Shichinohe, Hideo Browse this author →KAKEN DB | | Nakayama, Naoki Browse this author →KAKEN DB | | Kazumata, Ken Browse this author | | Hida, Kazutoshi Browse this author →KAKEN DB | | Houkin, Kiyohiro Browse this author →KAKEN DB |
| Keywords: | blood viscosity | | ischemic stroke | | small artery occlusion | | pathogenesis | | rheology | | dehydration |
| Issue Date: | Nov-2016 |
| Publisher: | Elsevier |
| Journal Title: | Journal of Stroke and Cerebrovascular Diseases |
| Volume: | 25 |
| Issue: | 11 |
| Start Page: | 2762 |
| End Page: | 2769 |
| Publisher DOI: | 10.1016/j.jstrokecerebrovasdis.2016.07.031 |
| PMID: | 27503271 |
| Abstract: | Background and Purpose: High blood viscosity causes blood stagnation and subsequent pathological thrombotic events, resulting in the development of ischemic stroke. We hypothesize that the contribution of blood viscosity may differ among ischemic stroke subtypes based on specific pathological conditions. We tried to verify this hypothesis by measuring blood viscosity in acute ischemic stroke patients using a newly developed electromagnetic spinning sphere (EMS) viscometer. Methods: Measurements in acute ischemic stroke patients were performed 4 times during admission and data were compared with those obtained from 100 healthy outpatient volunteers. Results: We enrolled 92 patients (cardioembolism [CE]: 25, large-artery atherosclerosis [LAA]: 42, and small artery occlusion [SAO]: 25) in this study. Comparisons of blood viscosity between the ischemic stroke subgroups and control group revealed that blood viscosity at the date of admission was significantly higher in the SAO group (5.37±1.11 mPa・s) than in the control group (4.66±0.72 mPa・s) (p<0.01). Among all subtype groups showing a reduction in blood viscosity after 2 weeks, the SAO group showed the highest and most significant reduction, indicating that SAO patients had the most concentrated blood at the onset. Conclusions: Blood viscosity was significantly increased in the SAO group at the date of admission, which indicated the contribution of dehydration to the onset of ischemic stroke. The importance of dehydration needs to be emphasized more in the pathogenesis of SAO. The clinical application of the EMS viscometer is promising for understanding and differentiating the pathogenesis of ischemic stroke. |
| Rights: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/67492 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 鐙谷 武雄
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