| Title: | Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer |
| Authors: | Yamashita, Hiroko Browse this author →KAKEN DB |
| Ogiya, Akiko Browse this author |
| Shien, Tadahiko Browse this author →KAKEN DB |
| Horimoto, Yoshiya Browse this author |
| Masuda, Norikazu Browse this author |
| Inao, Touko Browse this author |
| Osako, Tomofumi Browse this author |
| Takahashi, Masato Browse this author |
| Endo, Yumi Browse this author →KAKEN DB |
| Hosoda, Mitsuchika Browse this author →KAKEN DB |
| Ishida, Naoko Browse this author |
| Horii, Rie Browse this author →KAKEN DB |
| Yamazaki, Kieko Browse this author |
| Miyoshi, Yuichiro Browse this author |
| Yasojima, Hiroyuki Browse this author |
| Tomioka, Nobumoto Browse this author |
| Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society Browse this author |
| Keywords: | breast cancer |
| late recurrence |
| early recurrence |
| estrogen receptor positive |
| HER2 negative |
| estrogen receptor-positive |
| HER2-negative |
| Issue Date: | Nov-2016 |
| Publisher: | Springer |
| Journal Title: | Breast cancer |
| Volume: | 23 |
| Issue: | 6 |
| Start Page: | 830 |
| End Page: | 843 |
| Publisher DOI: | 10.1007/s12282-015-0649-0 |
| PMID: | 26467036 |
| Abstract: | Background: Most studies analyzing prognostic factors for late relapse have been performed in postmenopausal women who received tamoxifen or aromatase inhibitors as adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer. Methods: A total of 223 patients (108 premenopausal and 115 postmenopausal) with early distant recurrence and 149 patients (62 premenopausal and 87 postmenopausal) with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered from nine institutions. For each late recurrence patient, approximately two matched control patients without relapse for more than ten years were selected. Clinicopathological factors and adjuvant therapies were compared among the three groups by menopausal status and age. Results: Factors predicting early recurrence in premenopausal women were large tumor size, high lymph node category and high tumor grade, whereas predictors for late recurrence were large tumor size and high lymph node category. In postmenopausal women under 60 years of age, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, low PgR expression and high Ki67 labeling index (LI), while predictors for late recurrence were large tumor size and high lymph node category. On the other hand, in postmenopausal women aged 60 years or older, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, high tumor grade, low ER expression and high Ki67 LI, whereas predictors for late recurrence were high lymph node category, low ER expression and short duration of adjuvant endocrine therapy. Conclusion: Predictors of early and late distant recurrence might differ according to menopausal status and age. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/67497 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
