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Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/67497

Title: Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer
Authors: Yamashita, Hiroko Browse this author →KAKEN DB
Ogiya, Akiko Browse this author
Shien, Tadahiko Browse this author →KAKEN DB
Horimoto, Yoshiya Browse this author
Masuda, Norikazu Browse this author
Inao, Touko Browse this author
Osako, Tomofumi Browse this author
Takahashi, Masato Browse this author
Endo, Yumi Browse this author →KAKEN DB
Hosoda, Mitsuchika Browse this author →KAKEN DB
Ishida, Naoko Browse this author
Horii, Rie Browse this author →KAKEN DB
Yamazaki, Kieko Browse this author
Miyoshi, Yuichiro Browse this author
Yasojima, Hiroyuki Browse this author
Tomioka, Nobumoto Browse this author
Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society Browse this author
Keywords: breast cancer
late recurrence
early recurrence
estrogen receptor positive
HER2 negative
estrogen receptor-positive
HER2-negative
Issue Date: Nov-2016
Publisher: Springer
Journal Title: Breast cancer
Volume: 23
Issue: 6
Start Page: 830
End Page: 843
Publisher DOI: 10.1007/s12282-015-0649-0
PMID: 26467036
Abstract: Background: Most studies analyzing prognostic factors for late relapse have been performed in postmenopausal women who received tamoxifen or aromatase inhibitors as adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer. Methods: A total of 223 patients (108 premenopausal and 115 postmenopausal) with early distant recurrence and 149 patients (62 premenopausal and 87 postmenopausal) with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered from nine institutions. For each late recurrence patient, approximately two matched control patients without relapse for more than ten years were selected. Clinicopathological factors and adjuvant therapies were compared among the three groups by menopausal status and age. Results: Factors predicting early recurrence in premenopausal women were large tumor size, high lymph node category and high tumor grade, whereas predictors for late recurrence were large tumor size and high lymph node category. In postmenopausal women under 60 years of age, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, low PgR expression and high Ki67 labeling index (LI), while predictors for late recurrence were large tumor size and high lymph node category. On the other hand, in postmenopausal women aged 60 years or older, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, high tumor grade, low ER expression and high Ki67 LI, whereas predictors for late recurrence were high lymph node category, low ER expression and short duration of adjuvant endocrine therapy. Conclusion: Predictors of early and late distant recurrence might differ according to menopausal status and age.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/67497
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山下 啓子

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