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Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid

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Title: Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid
Other Titles: Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid
Autoantibody profile differentiates BP phenotypes
Authors: Izumi, Kentaro Browse this author →KAKEN DB
Nishie, Wataru Browse this author →KAKEN DB
Mai, Yosuke Browse this author
Wada, Mayumi Browse this author
Natsuga, Ken Browse this author →KAKEN DB
Ujiie, Hideyuki Browse this author →KAKEN DB
Iwata, Hiroaki Browse this author →KAKEN DB
Yamagami, Jun Browse this author →KAKEN DB
Shimizu, Hiroshi Browse this author →KAKEN DB
Keywords: autoantibody
bullous pemphigoid
collagen XVII
dipeptidyl peptidase-IV inhibitors
Issue Date: Nov-2016
Publisher: Elsevier
Journal Title: Journal of investigative dermatology
Volume: 136
Issue: 11
Start Page: 2201
End Page: 2210
Publisher DOI: 10.1016/j.jid.2016.06.622
PMID: 27424319
Abstract: Bullous pemphigoid (BP) is a major autoimmune blistering skin disorder, in which a majority of the autoantibodies (autoAbs) target the juxtamembranous extracellular noncollagenous 16A domain (NC16A) domain of hemidesmosomal collagen XVII. BP-autoAbs may target regions of collagen XVII other than the NC16A domain; however, correlations between epitopes of BP-autoAbs and clinical features have not been fully elucidated. To address correlations between the clinical features and specific epitopes of BP-autoAbs, we evaluated the epitope profiles of BP-autoAbs in 121 patients. A total of 87 patients showed a typical inflammatory phenotype with erythema and autoAbs targeting the anti-NC16A domain, whereas 14 patients showed a distinct noninflammatory phenotype, in which autoAbs specifically targeted the midportion of collagen XVII, but not NC16A. Interestingly, this group clinically showed significantly reduced erythema associated with scant lesional infiltration of eosinophils. Surprisingly, 7 of the 14 cases (50.0%) received dipeptidyl peptidase-IV inhibitors for the treatment of diabetes. Dipeptidyl peptidase-IV inhibitors were used in 3 of 76 (3.9%) typical cases of BP with autoAbs targeting NC16A; thus, dipeptidyl peptidase-IV inhibitors are thought to be involved in the development of atypical noninflammatory BP. This study shows that the autoAb profile differentiates between inflammatory and noninflammatory BP, and that noninflammatory BP may be associated with dipeptidyl peptidase-IV inhibitors.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 泉 健太郎

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