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The role of prophylactic neck dissection and tumor thickness evaluation for patients with cN0 tongue squamous cell carcinoma

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Title: The role of prophylactic neck dissection and tumor thickness evaluation for patients with cN0 tongue squamous cell carcinoma
Authors: Tsushima, Nayuta Browse this author
Sakashita, Tomohiro Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Kano, Satoshi Browse this author →KAKEN DB
Mizumachi, Takatsugu Browse this author →KAKEN DB
Kakizaki, Tomohiko Browse this author
Suzuki, Takayoshi Browse this author
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Tongue cancer
Nodal metastasis
Neck dissection
Tumor thickness
Issue Date: Nov-2016
Publisher: Springer
Journal Title: European Archives of Oto-Rhino-Laryngology
Volume: 273
Issue: 11
Start Page: 3987
End Page: 3992
Publisher DOI: 10.1007/s00405-016-4077-3
PMID: 27149875
Abstract: Purpose. Prophylactic neck dissection (PND) for patients with clinically N0 (cN0) tongue carcinoma remains controversial. We assessed the efficacy of PND for patients with cN0 tongue squamous cell carcinoma (SCC) and investigated the prognostic role of tumor thickness as assessed by diagnostic imaging in predicting the risk of nodal micrometastasis or late nodal recurrence. Methods. Eighty-eight patients with cN0 tongue carcinomas underwent surgical treatment. Tumor thickness was measured from magnetic resonance (MR) images or computed tomography (CT) scans. Results. The overall survival rates of patients with or without PND were 94% and 81%, respectively (p=0.2857). MR images or CT scans were available for 68 patients. A tumor thickness ≧10mm or ≧5mm did not increase the probability of nodal metastasis, with late nodal metastasis observed in 15% of patients with graphically undetected small tumors. Conclusions. PND appears to have the potential to improve overall survival for patients with cN0 tongue SCC. Careful follow-up management or PND is considered to be needed regardless of tumor thickness in the pre-treatment evaluation.
Rights: The final publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/67500
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 本間 明宏

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