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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
Successful Treatment of Sudden Hepatitis Induced by Long-Term Nivolumab Administration
This item is licensed under:Creative Commons Attribution-NonCommercial 4.0 International
| Title: | Successful Treatment of Sudden Hepatitis Induced by Long-Term Nivolumab Administration |
| Authors: | Imafuku, Keisuke Browse this author | | Yoshino, Koji Browse this author | | Yamaguchi, Kei Browse this author | | Tsuboi, Satoshi Browse this author | | Ohara, Kuniaki Browse this author | | Hata, Hiroo Browse this author →KAKEN DB |
| Keywords: | Malignant melanoma | | Nivolumab | | Hepatitis | | Long-term administration | | Successful treatment |
| Issue Date: | 24-Apr-2017 |
| Publisher: | Karger |
| Journal Title: | Case reports in oncology |
| Volume: | 10 |
| Issue: | 1 |
| Start Page: | 368 |
| End Page: | 371 |
| Publisher DOI: | 10.1159/000471480 |
| Abstract: | Immune checkpoint inhibitors have drastically changed in the treatment of many kinds of malignancies, especially malignant melanoma. The focus of the recent experiments has not only been on their efficacy but also immune-related adverse events (irAEs). We report a case of fulminant hepatitis due to nivolumab. In this case, the patient had undergone long-term nivolumab therapy. He did not complain of any symptoms but his liver enzyme levels were extremely elevated (grade 4). We promptly decided to start oral corticosteroids in the patient. His liver function rapidly improved. The dose of corticosteroids was gradually reduced. Our case demonstrates that sudden onset fulminant hepatitis can occur despite the safe use of long-term nivolumab therapy. The irAE can improve rapidly with proper corticosteroid treatment. This report will be useful for the physicians who always use immune checkpoint inhibitors. |
| Rights: | The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000471480 | | https://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/67550 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 秦 洋郎
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