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Successful Treatment of Sudden Hepatitis Induced by Long-Term Nivolumab Administration

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Title: Successful Treatment of Sudden Hepatitis Induced by Long-Term Nivolumab Administration
Authors: Imafuku, Keisuke Browse this author
Yoshino, Koji Browse this author
Yamaguchi, Kei Browse this author
Tsuboi, Satoshi Browse this author
Ohara, Kuniaki Browse this author
Hata, Hiroo Browse this author →KAKEN DB
Keywords: Malignant melanoma
Nivolumab
Hepatitis
Long-term administration
Successful treatment
Issue Date: 24-Apr-2017
Publisher: Karger
Journal Title: Case reports in oncology
Volume: 10
Issue: 1
Start Page: 368
End Page: 371
Publisher DOI: 10.1159/000471480
Abstract: Immune checkpoint inhibitors have drastically changed in the treatment of many kinds of malignancies, especially malignant melanoma. The focus of the recent experiments has not only been on their efficacy but also immune-related adverse events (irAEs). We report a case of fulminant hepatitis due to nivolumab. In this case, the patient had undergone long-term nivolumab therapy. He did not complain of any symptoms but his liver enzyme levels were extremely elevated (grade 4). We promptly decided to start oral corticosteroids in the patient. His liver function rapidly improved. The dose of corticosteroids was gradually reduced. Our case demonstrates that sudden onset fulminant hepatitis can occur despite the safe use of long-term nivolumab therapy. The irAE can improve rapidly with proper corticosteroid treatment. This report will be useful for the physicians who always use immune checkpoint inhibitors.
Rights: The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000471480
https://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/67550
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 秦 洋郎

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