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Genetic and environmental factors and serum hormones, and risk of estrogen receptor-positive breast cancer in pre- and postmenopausal Japanese women

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/67554

タイトル: Genetic and environmental factors and serum hormones, and risk of estrogen receptor-positive breast cancer in pre- and postmenopausal Japanese women
著者: Guo, Jiazhi 著作を一覧する
Sueta, Aiko 著作を一覧する
Nakamura, Koshi 著作を一覧する
Yoshimoto, Nobuyasu 著作を一覧する
Baba, Motoi 著作を一覧する
Ishida, Naoko 著作を一覧する
Hagio, Kanako 著作を一覧する
Toyama, Tatsuya 著作を一覧する
Iwase, Hirotaka 著作を一覧する
Tamakoshi, Akiko 著作を一覧する
Yamashita, Hiroko 著作を一覧する
キーワード: breast cancer
estrogen receptor-positive
risk predictor
genetic variants
25-hydroxyvitamin D
発行日: 2017年 9月12日
出版者: Impact Journals
誌名: Oncotarget
巻: 8
号: 39
開始ページ: 65759
終了ページ: 65769
出版社 DOI: 10.18632/oncotarget.20182
抄録: Breast cancer incidence in Japanese women has more than tripled over the past two decades. We have previously shown that this marked increase is mostly due to an increase in the estrogen receptor (ER)-positive, HER2-negative subtype. We conducted a case-control study; ER-positive, HER2-negative breast cancer patients who were diagnosed since 2011 and women without disease were recruited. Environmental factors, serum levels of testosterone and 25-hydroxyvitamin D, and common genetic variants reported as predictors of ER-positive breast cancer or found in Asian women were evaluated between patients and controls in pre-and postmenopausal women. To identify important risk predictors, risk prediction models were created by logistic regression models. In premenopausal women, two environmental factors (history of breastfeeding, and history of benign breast disease) and four genetic variants (TOX3-rs3803662, ESR1-rs2046210, 8q24-rs13281615, and SLC4A7-rs4973768) were considered to be risk predictors, whereas three environmental factors (body mass index, history of breastfeeding, and hyperlipidemia), serum levels of testosterone and 25-hydroxyvitamin D, and two genetic variants (TOX3-rs3803662 and ESR1-rs2046210) were identified as risk predictors. Inclusion of common genetic variants and serum hormone measurements as well as environmental factors improved risk assessment models. The decline in the birthrate according to recent changes of lifestyle might be the main cause of the recent notable increase in the incidence of ER-positive breast cancer in Japanese women.
資料タイプ: article
URI: http://hdl.handle.net/2115/67554
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 山下 啓子

 

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