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Genetic and environmental factors and serum hormones, and risk of estrogen receptor-positive breast cancer in pre- and postmenopausal Japanese women

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Title: Genetic and environmental factors and serum hormones, and risk of estrogen receptor-positive breast cancer in pre- and postmenopausal Japanese women
Authors: Guo, Jiazhi Browse this author
Sueta, Aiko Browse this author
Nakamura, Koshi Browse this author →KAKEN DB
Yoshimoto, Nobuyasu Browse this author
Baba, Motoi Browse this author
Ishida, Naoko Browse this author
Hagio, Kanako Browse this author
Toyama, Tatsuya Browse this author
Iwase, Hirotaka Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Yamashita, Hiroko Browse this author →KAKEN DB
Keywords: breast cancer
estrogen receptor-positive
risk predictor
genetic variants
25-hydroxyvitamin D
Issue Date: 12-Sep-2017
Publisher: Impact Journals
Journal Title: Oncotarget
Volume: 8
Issue: 39
Start Page: 65759
End Page: 65769
Publisher DOI: 10.18632/oncotarget.20182
Abstract: Breast cancer incidence in Japanese women has more than tripled over the past two decades. We have previously shown that this marked increase is mostly due to an increase in the estrogen receptor (ER)-positive, HER2-negative subtype. We conducted a case-control study; ER-positive, HER2-negative breast cancer patients who were diagnosed since 2011 and women without disease were recruited. Environmental factors, serum levels of testosterone and 25-hydroxyvitamin D, and common genetic variants reported as predictors of ER-positive breast cancer or found in Asian women were evaluated between patients and controls in pre-and postmenopausal women. To identify important risk predictors, risk prediction models were created by logistic regression models. In premenopausal women, two environmental factors (history of breastfeeding, and history of benign breast disease) and four genetic variants (TOX3-rs3803662, ESR1-rs2046210, 8q24-rs13281615, and SLC4A7-rs4973768) were considered to be risk predictors, whereas three environmental factors (body mass index, history of breastfeeding, and hyperlipidemia), serum levels of testosterone and 25-hydroxyvitamin D, and two genetic variants (TOX3-rs3803662 and ESR1-rs2046210) were identified as risk predictors. Inclusion of common genetic variants and serum hormone measurements as well as environmental factors improved risk assessment models. The decline in the birthrate according to recent changes of lifestyle might be the main cause of the recent notable increase in the incidence of ER-positive breast cancer in Japanese women.
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/67554
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山下 啓子

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