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Isolation of a simian immunodeficiency virus from a malbrouck (Chlorocebus cynosuros)

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Title: Isolation of a simian immunodeficiency virus from a malbrouck (Chlorocebus cynosuros)
Authors: Carr, Michael Browse this author
Kawaguchi, Akira Browse this author
Sasaki, Michihito Browse this author →KAKEN DB
Gonzalez, Gabriel Browse this author
Ito, Kimihito Browse this author →KAKEN DB
Thomas, Yuka Browse this author
Hang'ombe, Bernard M. Browse this author
Mweene, Aaron S. Browse this author
Zhao, Guoyan Browse this author
Wang, David Browse this author
Orba, Yasuko Browse this author →KAKEN DB
Ishii, Akihiro Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Keywords: Simian immunodeficiency virus
African green monkey
Chlorocebus cynosuros
next generation sequencing
virus discovery
Issue Date: 1-Nov-2016
Publisher: Springer
Journal Title: Archives of virology
Volume: 162
Issue: 2
Start Page: 543
End Page: 548
Publisher DOI: 10.1007/s00705-016-3129-8
PMID: 27804019
Abstract: To investigate the diversity of simian immunodeficiency virus (SIV) among nonhuman primates (NHPs) in Zambia, next-generation sequencing was performed to determine the complete genome sequence of a novel SIV recovered by co-culturing African green monkey (AGM) peripheral blood lymphocytes with human CD4(+) T-cell lines. We report the first described SIV (SIVagmMAL-ZMB) from a malbrouck (Chlorocebus cynosuros). SIVagmMAL-ZMB was detected by real-time PCR analysis of splenic RNA in 3.2% (3/94) of AGMs and was undetectable in baboons (0/105). SIVagmMAL-ZMB possessed < 80% nucleotide sequence identity to known SIV isolates and was located basally to vervet monkey SIV strains in all phylogenies.
Rights: The final publication is available at Springer via
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 澤 洋文

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