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Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion

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タイトル: Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion
著者: Kurisu, Kota 著作を一覧する
Abumiya, Takeo 著作を一覧する
Ito, Masaki 著作を一覧する
Gekka, Masayuki 著作を一覧する
Osanai, Toshiya 著作を一覧する
Shichinohe, Hideo 著作を一覧する
Nakayama, Naoki 著作を一覧する
Kazumata, Ken 著作を一覧する
Houkin, Kiyohiro 著作を一覧する
キーワード: Apoptosis
Gliosis
Hypothermia
Partial reperfusion injury
Permanent middle cerebral artery occlusion
Transarterial regional hypothermia
発行日: 2016年11月15日
出版者: Elsevier
誌名: Brain research
巻: 1651
開始ページ: 95
終了ページ: 103
出版社 DOI: 10.1016/j.brainres.2016.09.017
抄録: The robust neuroprotective effects of transarterial regional hypothermia have been demonstrated in the typical transient middle cerebral artery occlusion (tMCAO) model, but have not yet been tested in other ischemic stroke models, even though clinical ischemic conditions are diverse. In order to clarify these effects in a different ischemic stroke model, we employed a rat model of permanent MCAO (pMCAO) with transient collateral hypoperfusion (tCHP), which was achieved by direct MCA ligation through craniotomy and 1-h bilateral common carotid artery occlusion at the beginning of pMCAO. The infusion of 20 ml/kg of 4 degrees C cold saline (CS) or 37 degrees C warm saline (WS) into the ipsilateral internal carotid artery (ICA) was performed for 15 min in intra- or post-tCHP. Neurological scores, infarct/edema volumes, and neuronal apoptosis and reactive gliosis were compared between the CS and WS groups and a non-infusion control group after 48 h of reperfusion. Although brain temperatures were only reduced by 2-3 degrees C for 15 min, the CS group had significantly better neurological scores, smaller infarct/edema volumes, and less penumbral neuronal apoptosis and reactive gliosis than the control and WS groups. The post-tCHP CS group exhibited prominent neuroprotective effects, even though infarct volumes and neuronal apoptosis were reduced less than those in the intra-tCHP CS group. In conclusion, we demonstrated the neuroprotective effects of transarterial regional hypothermia in an ischemic model of pMCAO with tCHP. Even though MCAO is persistent, cold infusion via the ICA is neuroprotective for the penumbra, suggesting the wider therapeutic application of this therapy.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/67580
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 鐙谷 武雄

 

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