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Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets

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Title: Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets
Authors: Tsuda, Yoshimi Browse this author
Weisend, Carla Browse this author
Martellaro, Cynthia Browse this author
Feldmann, Friederike Browse this author
Haddock, Elaine Browse this author
Keywords: ferret
virus shedding
Issue Date: Aug-2017
Publisher: The Japanese Society of Veterinary Science
Journal Title: Journal of veterinary medical science
Volume: 79
Issue: 8
Start Page: 1453
End Page: 1460
Publisher DOI: 10.1292/jvms.16-0619
Abstract: The pandemic 2009 H1N1 influenza A virus emerged in humans and caused the first influenza pandemic of the 21st century. Mexican isolates, A/Mexico/4108/2009 (H1N1) (Mex4108) and A/Mexico/InDRE4478/2009 (H1N1) (Mex4487) derived from a mild case and from a cluster of severe cases, showed heterogeneity in virulence in a cynomolgus macaque model. To compare the more pathogenic differences, we generated recombinant viruses and compared their virulence in ferrets. Ferrets infected with recombinant Mex4487 displayed a slightly higher rate of viral replication and severe pneumonia in the early stage of infection. In contrast, prolonged lower virus shedding of recombinant Mex4108 than that of recombinant Mex4487 was detected in throat swabs. Thus, Mex4487 induces severe pneumonia in infected individuals, whereas Mex4108 might have wide-spreading potential with mild disease.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 津田 祥美

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