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Antibacterial and cytotoxic effects of photoexcited Au clusters via blue high-power or white low-power light emitting diode irradiation

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2017 miyata BEM-2-126.pdf489.02 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/67756

タイトル: Antibacterial and cytotoxic effects of photoexcited Au clusters via blue high-power or white low-power light emitting diode irradiation
著者: Miyata, Saori 著作を一覧する
Miyaji, Hirofumi 著作を一覧する
Kawasaki, Hideya 著作を一覧する
Nishida, Erika 著作を一覧する
Shitomi, Kanako 著作を一覧する
Akasaka, Tsukasa 著作を一覧する
Tanaka, Saori 著作を一覧する
Iizuka, Tadashi 著作を一覧する
Sugaya, Tsutomu 著作を一覧する
キーワード: Antimicrobial photodynamic therapy
captopril-protected gold (Au) clusters
lysozyme-stabilized gold clusters
photosensitizer
Streptococcus mutans
発行日: 2017年10月
出版者: Open Access Text
誌名: Biology, Engineering and Medicine
巻: 2
号: 4
出版社 DOI: 10.15761/BEM.1000126
抄録: The development of photosensitizers and light sources has enabled the use of antimicrobial photodynamic therapy (aPDT) in various dental therapies. In the present study, we compared the antibacterial and cytotoxic effects of Au clusters photoexcited by blue and white LED irradiation. We fabricated novel photosensitizers, captopril-protected gold (Capt-Au) clusters and lysozyme-stabilized gold (Lyz-Au) clusters, for aPDT. Au clusters were then photoexcited by two kinds of light sources, blue high-power and white low-power light-emitting diodes (LEDs). Since white LED contains a wide spectrum of light (400–750 nm), white LED would be relevant for aPDT even if using a low-power source. The turbidity and viability of Streptococcus mutans were assessed following application of Capt-Au clusters (500 μg/mL) or Lyz-Au clusters (1,000 μg/mL) photoexcited by a blue high-power LED (1,000 mW/cm2) or white low-power LED (80 mW/cm2). In addition, the cytotoxicity of Au clusters and LED irradiation was evaluated in NIH3T3 and MC3T3-E1 cells. Au clusters photoexcited by the white low-power LED equally decreased the turbidity and viability of S. mutans compared with blue high-power LED. However, Au clusters photoexcited by white LED irradiation caused decreased cytotoxicity in mammalian cells compared with those photoexcited by blue LED irradiation. In conclusion, white LEDs possess biosafe properties for aPDT using Au clusters.
資料タイプ: article
URI: http://hdl.handle.net/2115/67756
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 宮治 裕史

 

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