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One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation

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Title: One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
Authors: Dupré de Baubigny, Julien Browse this author
Trégouët, Corentin Browse this author
Salez, Thomas Browse this author
Pantoustier, Nadège Browse this author
Perrin, Patrick Browse this author
Reyssat, Mathilde Browse this author
Monteux, Cécile Browse this author
Issue Date: 28-Apr-2017
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 7
Start Page: 1265
Publisher DOI: 10.1038/s41598-017-01374-3
Abstract: Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. This robust process is realized through different methods, to obtain capsules of various sizes, from the micrometer scale using microfluidics or rotor-stator emulsification up to the centimeter scale using drop dripping. The polymer layer exhibits unique self-healing and pH-responsive properties. The membrane is viscoelastic at pH=3, softens as pH is progressively raised, and eventually dissolves above pH=6 to release the oil phase. This one-step method of preparation paves the way to the production of large quantities of functional capsules.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)


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