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Fate and tissue depletion of nivalenol in ducks

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Title: Fate and tissue depletion of nivalenol in ducks
Authors: Amnart, Poapolathep Browse this author
Saranya, Poapolathep Browse this author
Piyaluk, Sinphithakkul Browse this author
Kanjana, Imsilp Browse this author
Supaporn, Isariyodom Browse this author
Usuma, Jermnak Browse this author
Phanwimol, Tanhan Browse this author
Helen, Owen Browse this author
Mario, Giorgi Browse this author
Keywords: nivalenol
Issue Date: Nov-2017
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 65
Issue: 4
Start Page: 185
End Page: 192
Abstract: Nivalenol (NIV), a mycotoxin belonging to the trichothecenes type B group, has recently been identified as causing one of the more potent toxicities among mycotoxins of this group. The purpose of this study was to clarify the toxicokinetics, and residues of NIV in ducks. Then, NIV was administered intravenously (iv) or orally (po) to ducks at a dosage of 0.8 mg/kg body weight. The concentrations of NIV in plasma and various tissues were quantified using liquid chromatography tandem-mass spectrometry. The plasma concentrations of NIV were measurable up to 12 h after iv and po administrations, respectively. A non-compartmental model was used to describe the toxicokinetics of NIV in ducks. The values of elimination half-life and volume of distribution were 2.24 ± 0.34 h and 1081.87 ± 306.56 ml/kg, respectively, after iv administration. The absolute oral bioavailability was 8.91 ± 1.69%. NIV was measurable in the vital organs after po administration. These results suggest that NIV is not favorably absorbed from the gastrointestinal tract, but it has the ability to penetrate into the various tissues of ducks.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 65 Number 4

Submitter: 獣医学部図書室

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