HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Japanese Journal of Veterinary Research >
Volume 65 Number 4 >

Case Report: Congenital methemoglobinemia in a cat with the reduced NADH-cytochrome b5 reductase 3 activity and missense mutations in CYB5R3

Files in This Item:
p201-206 Mutsumi Inaba.pdf687.98 kBPDFView/Open
Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.65.4.201

Title: Case Report: Congenital methemoglobinemia in a cat with the reduced NADH-cytochrome b5 reductase 3 activity and missense mutations in CYB5R3
Authors: Tani, Akiyoshi Browse this author
Yamazaki, Jumpei Browse this author
Nakamura, Kensuke Browse this author
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Inaba, Mutsumi Browse this author →KAKEN DB
Keywords: Cyanosis
Cytochrome b5 reductase
Methemoglobinemia
Issue Date: Nov-2017
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 65
Issue: 4
Start Page: 201
End Page: 206
Abstract: A one-year-old castrated male mixed-breed cat was referred for detailed examination of long-term pale mucous membrane without any clinical episodes that may cause cyanosis. While no causative abnormalities were detected in thoracic radiography and echocardiography, and arterial partial pressure of oxygen was within normal value, methemoglobin concentration of the cat was increased to 30% and cytochrome b5 reductase activity, which converts methemoglobin to hemoglobin, was reduced to 2.0 IU/gHb (13.4 ± 1.7 IU/gHb in control cats, n = 3), indicating congenital methemoglobinemia. Sequence analysis of CYB5R3, which codes cytochrome b5 reductase, showed two missense mutations found in the patient, one of which was predicted to affect protein function.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/67879
Appears in Collections:Japanese Journal of Veterinary Research > Volume 65 Number 4

Submitter: 獣医学部図書室

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University