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Volume 65 Number 4 >

Assessment of the growth inhibitory effect of gellan sulfate in rodent malaria in vivo

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Title: Assessment of the growth inhibitory effect of gellan sulfate in rodent malaria in vivo
Authors: Recuenco, Frances C. Browse this author
Takano, Ryo Browse this author
Sugi, Tatsuki Browse this author
Takemae, Hitoshi Browse this author
Murakoshi, Fumi Browse this author
Ishiwa, Akiko Browse this author
Inomata, Atsuko Browse this author
Enomoto-Rogers, Yukiko Browse this author
Fundador, Noreen Grace V. Browse this author
Iwata, Tadahisa Browse this author
Horimoto, Taisuke Browse this author →KAKEN DB
Akashi, Hiroomi Browse this author
Kato, Kentaro Browse this author
Keywords: Gellan sulfate
in vivo
rodent malaria
Issue Date: Nov-2017
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 65
Issue: 4
Start Page: 207
End Page: 212
Abstract: In our effort to discover novel antimalarials, we previously synthesized gellan sulfate, a novel anticoagulant derivative of gellan gum and showed that it inhibits the growth and invasion of erythrocytes by Plasmodium falciparum parasites in vitro (Recuenco et al. 2014. Sci Rep. 4:4723.). Gellan sulfate was also found to have low cytotoxicity and low anticoagulant activities in vitro. Here, we assessed gellan sulfate for its antimalarial effects in vivo. Despite its effectiveness in vitro, gellan sulfate inhibited the growth of both P. berghei ANKA and P. yoelii 17XL poorly in C57BL/6 and BALB/c mice, respectively. To our knowledge, this is the first work that uses gellan gum and gellan sulfate for intraperitoneal injection in mice.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 65 Number 4

Submitter: 獣医学部図書室

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